Per- and Poly-fluoroalkyl Substances (PFAS) (Chemicals and Contaminants).

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI:10.14252/foodsafetyfscj.D-25-00009
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Abstract

Food Safety Commission of Japan (FSCJ) conducted a self-tasking risk assessment of per- and poly-fluoroalkyl substances (PFAS) in food. Scientific findings and risk evaluation data regarding PFAS, of international organizations, government agencies in other countries, etc., were reviewed in the current risk assessment. The scientific literature related to three major compounds of PFAS, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS), was surveyed and served for the discussion. Reference doses were derived from two animal experiments* described below. To determine the reference dose, dose estimation models developed by overseas evaluation institutions were adopted for conversion of POD (point of departure) in animal experiments to PODHED (Human Equivalent Dose). Based on the discussions and estimation, the tolerable daily intake (TDI) was appropriately set as 20 ng/kg body weight/day (2×10-5 mg/kg body weight/day) for PFOS and as 20 ng/kg body weight/day (2×10-5 mg/kg body weight/day) for PFOA. Insufficient scientific findings precluded the evaluation to specify a reference dose of PFHxS. The average daily intake in Japan was obtained from the Total Diet Study conducted in a limited number of regions during the fiscal years 2012-2014: PFOS (Lower Bound to Upper Bound (LB-UB)** 0.60-1.1 ng/kg body weight/day, and PFOA (LB-UB) 0.066-0.75 ng/kg body weight/day. These values were lower than the TDIs. Due to the lack of sufficient data on PFAS concentrations and their distribution in various foods, it is necessary to be aware of these intake estimates carrying considerable uncertainty.

全氟和多氟烷基物质(PFAS)(化学品和污染物)。
日本食品安全委员会(FSCJ)对食品中的单氟烷基和多氟烷基物质(PFAS)进行了自我任务风险评估。本风险评估综述了国际组织、其他国家政府机构等关于PFAS的科学发现和风险评估数据。调查了与全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和全氟己烷磺酸(PFHxS)这三种主要化合物有关的科学文献,供讨论之用。参考剂量来自下面描述的两个动物实验*。为确定参考剂量,采用国外评价机构开发的剂量估计模型,将动物实验中的出发点(POD)换算为人体等效剂量(PODHED)。通过讨论和估算,确定全氟辛烷磺酸的耐受日摄入量为20 ng/kg体重/天(2×10-5 mg/kg体重/天),全氟辛烷磺酸的耐受日摄入量为20 ng/kg体重/天(2×10-5 mg/kg体重/天)。由于科学发现不足,无法确定PFHxS的参考剂量。日本的平均每日摄入量来自2012-2014财政年度在少数地区进行的总饮食研究:全氟辛烷磺酸(下限至上限(LB-UB)** 0.60-1.1纳克/千克体重/天,全氟辛烷磺酸(LB-UB) 0.066-0.75纳克/千克体重/天。这些数值低于tdi。由于缺乏关于PFAS浓度及其在各种食物中的分布的足够数据,有必要认识到这些摄入量估计具有相当大的不确定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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