Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.

IF 2.7 3区医学 Q3 NEUROSCIENCES

Brain Sciences Pub Date : 2025-03-11 DOI:10.3390/brainsci15030295

Fahad H Alhazmi

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引用次数: 0

Abstract

Background/objectives: Chronotypes significantly influence sleep quality, daily performance, and overall activity levels. Although there is growing evidence indicating that individuals with a late chronotype are more likely to experience cognitive decline, the specific neural mechanisms that contribute to this risk remain unclear. This study aims to explore the relationship between morning and evening preferences and the volumes of subcortical structures in a young, healthy population.

Methods: A total of 123 participants (80 females), aged between 18 and 35 years, were recruited. They underwent MRI scans and completed several self-reported assessments, including the morningness-eveningness scale of the Chronotype Questionnaire (ChQ-ME), the amplitude scale of the Chronotype Questionnaire (ChQ-AM), the Epworth Sleepiness Scale (ESS), and the Pittsburgh Sleep Quality Index (PSQI). Participants were classified into early chronotype (EC) and late chronotype (LC) groups based on their ChQ-ME scores. High-resolution T1-weighted imaging was utilized to analyze the volumes of subcortical structures and hippocampal subfields.

Results: The volumetric analysis indicated that the LC group showed significant reductions in the right Caudate (p = 0.03) and the left SR-SL-SM (p = 0.03) compared to the EC group. Additionally, a notable leftward hemispheric laterality of the Subiculum (p = 0.048) was observed in the EC group relative to the LC group. Furthermore, the ChQ-AM revealed significant positive (r = 0.23) and negative (r = -0.19) correlations with the volumes of the left thalamus and right amygdala, respectively. The PSQI demonstrated a significant negative correlation (r = -0.21) with the right SR-SL-SM, while the ESS indicated a significant positive correlation (r = 0.24) with the left SR-SL-SM. Multiple regression analysis indicated that variations in daytime sleepiness are linked to the change of the left SR-SL-SM volume.

Conclusions: Overall, the findings suggest that chronotype preferences are associated with the changes in the volumes of subcortical structures and hippocampal subfields and highlight the role of chronotypes in the neural mechanisms of these brain structures.

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青少年健康人群睡眠时型与皮质下结构和海马亚区体积的相关性研究。

背景/目的：睡眠类型显著影响睡眠质量、日常表现和整体活动水平。尽管越来越多的证据表明，时间类型较晚的人更有可能经历认知能力下降，但导致这种风险的具体神经机制仍不清楚。本研究旨在探索年轻健康人群的早晚偏好与皮层下结构体积之间的关系。方法：共招募123名参与者（80名女性），年龄在18 ~ 35岁之间。他们接受了核磁共振扫描，并完成了几项自我报告评估，包括睡眠类型问卷（ChQ-ME）的清晨-晚上量表、睡眠类型问卷（ChQ-AM）的振幅量表、爱普沃斯嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI）。根据参与者的ChQ-ME得分，将他们分为早期睡眠类型（EC）和晚期睡眠类型（LC）组。采用高分辨率t1加权成像分析皮质下结构和海马亚区体积。结果：体积分析显示，LC组与EC组相比，右侧尾状核（p = 0.03）和左侧SR-SL-SM （p = 0.03）明显减少。此外，相对于LC组，EC组观察到显著的耻骨下半球偏左（p = 0.048）。此外，ChQ-AM分别与左丘脑和右杏仁核体积呈显著正相关（r = 0.23）和负相关（r = -0.19）。PSQI与右侧SR-SL-SM呈显著负相关（r = -0.21）， ESS与左侧SR-SL-SM呈显著正相关（r = 0.24）。多元回归分析表明，白天嗜睡的变化与左侧SR-SL-SM体积的变化有关。结论：总的来说，研究结果表明，时间类型偏好与皮层下结构和海马亚区体积的变化有关，并突出了时间类型在这些大脑结构的神经机制中的作用。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.