The Impact of Walking on BDNF as a Biomarker of Neuroplasticity: A Systematic Review.

IF 2.7 3区医学 Q3 NEUROSCIENCES

Brain Sciences Pub Date : 2025-02-27 DOI:10.3390/brainsci15030254

Mohamed Hesham Khalil

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引用次数: 0

Abstract

Background/objectives: The brain-derived neurotrophic factor (BDNF) is a critical exercise-induced modulator of various neuroplasticity processes, including adult hippocampal neurogenesis. Environmental affordance for physical activity is a novel theory that aims to increase the BDNF through walking or climbing stairs, stimulated by the urban and interior environment. In a systematic review, this paper explores the association between walking, as a structured or free-living form of physical activity, and changes in the BDNF in humans with healthy locomotion.

Method: A systematic review with a registered protocol, INPLASY2024110093, and following the PRISMA guidelines, includes English-language original research articles on adult and older adult human subjects who are locomotor-healthy, studies on walking as a structured exercise or free-living physical activity that is presented in a non-combined intervention, and must report changes in the BDNF as a dependent variable. The search was conducted using three databases: PubMed, Web of Science, and Scopus, resulting in 21 eligible studies.

Results: This systematic review finds that the impact of walking on the BDNF is evidenced, but subject to moderate to high intensities in single bouts. At the same time, the long-term effects are yet to be fully understood, potentially due to the uptake of the BDNF for functional brain improvements, neuroplasticity processes, or muscle repair, instead of an accumulation of the BDNF itself, yet still confirm the important role of the BDNF for neurosustainability. Age and environmental factors such as heat are also found to affect the increase in the BDNF. The narrative synthesis provides elaborate explanations for understanding those complex dynamics before reaching future conclusions on the impact of walking or environmental affordance for physical activity on the changes in the BDNF concentrations.

Conclusions: This systematic review highlights the potential role played by moderate- and high-intensity walking as a lifestyle intervention that can be utilised through the built environment to promote adaptive brain changes, through the sustainable regulation of the BDNF.

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步行对BDNF作为神经可塑性生物标志物的影响：系统综述。

背景/目的：脑源性神经营养因子（BDNF）是运动诱导的各种神经可塑性过程的关键调节剂，包括成人海马神经发生。体育活动的环境支持是一个新的理论，旨在通过步行或爬楼梯来增加BDNF，在城市和室内环境的刺激下。在一篇系统综述中，本文探讨了步行作为一种有组织的或自由生活的身体活动形式与健康运动人群中BDNF变化之间的关系。方法：系统回顾注册方案INPLASY2024110093，并遵循PRISMA指南，包括成人和老年人运动健康的英语原创研究文章，将步行作为一种有组织的锻炼或自由生活的身体活动的研究，在非联合干预中，必须报告BDNF作为因变量的变化。检索使用三个数据库：PubMed、Web of Science和Scopus，最终得到21项符合条件的研究。结果：本系统综述发现，步行对BDNF的影响是有证据的，但需要在单次运动中进行中等到高强度的运动。与此同时，其长期影响尚不完全清楚，可能是由于BDNF的摄取用于脑功能改善、神经可塑性过程或肌肉修复，而不是BDNF本身的积累，但仍然证实了BDNF在神经可持续性方面的重要作用。年龄和热等环境因素也会影响BDNF的增加。在得出关于步行或环境对身体活动的影响对BDNF浓度变化的影响的未来结论之前，叙述性综合为理解这些复杂的动力学提供了详细的解释。结论：本系统综述强调了中等和高强度步行作为一种生活方式干预所发挥的潜在作用，可以通过建筑环境促进适应性大脑变化，通过BDNF的可持续调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.