Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury.

IF 2.7 3区医学 Q3 NEUROSCIENCES

Brain Sciences Pub Date : 2025-02-27 DOI:10.3390/brainsci15030251

Juan Sebastián Jara, Marwa A Soliman, Amanda Bernstein, Paola di Grazia, Adam R Ferguson, Justin M Brown, Abel Torres-Espín, Edmund R Hollis

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引用次数: 0

Abstract

Background/objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this intervention, variability in outcomes can limit the functional impact. A bedside to bench approach was taken to address the variable response of tetraplegic individuals to nerve transfer surgery.

Methods: We used a hierarchical multiple factor analysis to evaluate the effects of conditioning electrical stimulation (CES) on outcomes in a mouse model of nerve transfer to treat chronic cervical spinal cord injury.

Results: We found that CES of donor nerves one week prior to nerve transfer surgery enhanced anatomical and functional measures of innervation of targeted muscles. Furthermore, CES increased the rate of recovery of naturalistic behavior.

Conclusions: While the model has some limitations due to the small size of the rodent, our results support the use of CES as an effective approach to improve outcomes in clinical nerve repair settings.

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调节神经电刺激增强神经移植治疗慢性脊髓损伤小鼠模型的功能重布线。

背景/目的：神经转移手术是一种最先进的手术方法，用于恢复四肢瘫痪患者的手和手臂功能，显著影响日常生活。虽然近三分之一的慢性脊髓损伤患者可能从这种干预中受益，但结果的可变性可能会限制功能影响。采用床边到台架的方法来解决四肢瘫痪个体对神经转移手术的可变反应。方法：采用分层多因素分析评价调节电刺激（CES）对神经移植治疗慢性颈脊髓损伤小鼠模型预后的影响。结果：我们发现，在神经移植手术前一周，供体神经的CES增强了目标肌肉神经支配的解剖和功能测量。此外，CES提高了自然行为的恢复率。结论：虽然由于啮齿动物的体型较小，该模型存在一些局限性，但我们的研究结果支持将CES作为改善临床神经修复效果的有效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.