Association of plasma zinc and copper levels with mild cognitive impairment in patients with type 2 diabetes.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1532080

Yang Jiao, Xing Zhang, Lian Duan, Ruijie Cheng, Ning Yang, Zhao Peng, Ben Li, Lu Xu, Wenwen Chen, Jingrong Chen, Yanchao Liu, Hong Yan

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引用次数: 0

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a significant risk factor for cognitive impairment. Zinc deficiency contributes to T2DM development, while copper may exacerbate diabetes through prooxidant mechanisms. Higher zinc levels may protect against copper toxicity. This study investigates the association of plasma zinc and copper levels with mild cognitive impairment (MCI) in T2DM patients.

Methods: T2DM patients admitted to Tongji Hospital from 2012 to 2018 were classified into MCI (n = 136) and control (n = 136) groups, matched by age (± 3 years) and gender. Conditional logistic regression was used to assess the associations between plasma zinc, copper levels and MCI. A generalized additive model (GAM) evaluated the dose-response relationship between plasma zinc, copper levels and Mini-Mental State Examination (MMSE) scores.

Results: The median of plasma metal levels in MCI and control groups were 831.31 μg/L and 936.29 μg/L for zinc, 932.07 μg/L and 860.47 μg/L for copper, and 0.91 and 1.11 for the zinc-to-copper (Zn/Cu) ratio. Compared to participants in the lowest tertile, the multivariable-adjusted odds ratios with 95% confidence intervals (CI) for MCI in the highest tertile were 0.33 (0.13, 0.79) for zinc, 3.56 (1.42, 8.94) for copper, and 0.37 (0.15, 0.93) for the Zn/Cu ratio. Plasma Aβ40 levels were significantly lower (p = 0.009) and plasma Aβ42/40 levels were significantly higher (p = 0.008) in MCI group compared with those in control group. Zinc concentration was positively associated with Aβ42. For per SD (327.71 μg/L) increase in plasma zinc levels, the percent change (95% CI) of Aβ42 were 2.90 (0.85, 4.99).

Conclusion: Higher plasma zinc levels and higher Zn/Cu ratio were associated with lower odds of MCI in T2DM patients, while higher copper levels increased the risk of MCI. This study provides insights on plasma zinc, copper, and Zn/Cu ratio and Aβ of MCI, further studies are needed to clarify the underlying mechanisms for novel therapies that could prevent or cure multiple T2DM-related cognitive impairments.

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血浆锌和铜水平与2型糖尿病患者轻度认知障碍的关系

背景：2型糖尿病（T2DM）是认知功能障碍的重要危险因素。锌缺乏有助于2型糖尿病的发展，而铜可能通过促进机制加重糖尿病。较高的锌含量可以防止铜中毒。本研究探讨了血浆锌和铜水平与T2DM患者轻度认知障碍（MCI）的关系。方法：将2012 - 2018年同济医院收治的T2DM患者分为MCI组（n = 136）和对照组（n = 136），按年龄（±3 岁）和性别匹配。使用条件逻辑回归来评估血浆锌、铜水平与MCI之间的关系。采用广义加性模型（GAM）评估血浆锌、铜水平与微量精神状态检查（MMSE）评分之间的剂量-反应关系。结果：MCI组和对照组血浆金属水平中位数锌分别为831.31 μg/L和936.29 μg/L，铜分别为932.07 μg/L和860.47 μg/L，锌铜比分别为0.91和1.11。与最低分位数的参与者相比，最高分位数的MCI的多变量调整比值比（95%置信区间CI）为锌0.33(0.13,0.79)，铜3.56(1.42,8.94)，锌/铜比0.37（0.15,0.93）。MCI组血浆Aβ40水平显著低于对照组（p = 0.009），血浆Aβ42/40水平显著高于对照组（p = 0.008）。锌浓度与Aβ42呈正相关。血浆锌水平每升高SD(327.71 μg/L)， Aβ42的变化百分比（95% CI）分别为2.90（0.85,4.99）。结论：较高的血浆锌水平和较高的锌铜比与T2DM患者发生MCI的几率较低相关，而较高的铜水平则增加了MCI的风险。本研究提供了血浆锌、铜、锌/铜比和Aβ在MCI中的作用，需要进一步的研究来阐明新疗法的潜在机制，以预防或治愈多发性t2dm相关的认知障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.