Non-Invasive structural analysis of packaged pharmaceuticals using different variants of spatially offset low-frequency Raman spectroscopy

IF 5.2 2区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Measurement Pub Date : 2025-03-20 DOI:10.1016/j.measurement.2025.117360

Kārlis Bērziņš , Lasse S. Krog , Ben J. Boyd

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Abstract

Three different variants of low-frequency Raman (LFR) spectroscopy (<300 cm⁻¹) with spatially offset configurations were explored for the in situ analysis of packaged pharmaceuticals and compared with the more typically used mid-frequency or fingerprint spectral domain (300–1800 cm⁻¹). A range of scenarios were tested including different types of packaging, analysis of mixtures and real-time monitoring of dynamic structural changes where each of the optical configurations (defocusing displacement, point-like offset and transmission) presented certain advantages and disadvantages for the analysis. Nevertheless, in all instances, the higher signal propensity and structural sensitivity of the LFR regime either facilitated or improved the analysis. These results allude to a promising future for the broader adaption of spatially-offset LFR spectroscopy for the dissemination of packaged goods, with the potential development of LFR-enabled hand-held devices to tackle specific applications.

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来源期刊

Measurement 工程技术-工程：综合

CiteScore

10.20

自引率

12.50%

发文量

1589

审稿时长

12.1 months

期刊介绍： Contributions are invited on novel achievements in all fields of measurement and instrumentation science and technology. Authors are encouraged to submit novel material, whose ultimate goal is an advancement in the state of the art of: measurement and metrology fundamentals, sensors, measurement instruments, measurement and estimation techniques, measurement data processing and fusion algorithms, evaluation procedures and methodologies for plants and industrial processes, performance analysis of systems, processes and algorithms, mathematical models for measurement-oriented purposes, distributed measurement systems in a connected world.