A Case of Fluoroscopy-Induced Subacute Radiation Dermatitis Histologically Mimicking Sclerodermiform Lupus: Immunohistochemical Analysis of Cytotoxic Memory T-Cell Markers.

IF 1.6 4区 医学 Q3 DERMATOLOGY
Vidya Medepalli, Timar A Mascio, Anthony Thompson, Marc Inglese, Pamela Padilla, Stephen Richardson, András Schaffer
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Abstract

The histological hallmark of fluoroscopy-induced subacute radiation dermatitis (FISARD) is basovacuolar interface reaction with satellite cell necrosis mediated by CD8+ cytotoxic T-cells. Most published cases are described in patients who had a single interventional exposure. Here we report a case of FISARD in a 78-year-old man who underwent two cardiovascular interventions within 2 months. Biopsy of the skin lesion on his left back revealed not only epidermal cytotoxic interface activity with superficial perivascular dermatitis but also deep perivascular and interstitial dermal lymphoid infiltrates and dermal sclerosis, features overlapping with lupus and inflammatory morphea. Immunohistochemistry revealed intraepidermal and dermal expression of CD3, CD8, TIA-1, and CD45RA, likely corresponding to terminally differentiated effector memory cytotoxic T cells (TEMRA). In contrast, expression of CD57, a marker of late memory T-cells implicated in scleroderma pathogenesis, was absent in the epidermis but present in the dermis. This case adds to the spectrum of histopathologic findings of FISARD possibly related to the cumulative radiation injury from multiple fluoroscopic procedures. Given the increasing use of fluoroscopy, recognition of this histopathological pattern could aid in the timely and accurate diagnosis of this condition. A potential role of memory CD8+ T-cells in disease pathogenesis is discussed.

1例荧光镜诱导的亚急性放射性皮炎组织学模拟硬皮样狼疮:细胞毒性记忆t细胞标记物的免疫组织化学分析。
荧光镜诱导的亚急性放射性皮炎(FISARD)的组织学特征是基底空泡界面反应,伴有CD8+细胞毒性t细胞介导的卫星细胞坏死。大多数已发表的病例都是只接受过一次介入性暴露的患者。在此,我们报告一位78岁的男性患者在2个月内接受了两次心血管干预。左背部皮肤病变活检显示,不仅表皮细胞毒性界面活性表现为浅表血管周围皮炎,还表现为深部血管周围和间质性真皮淋巴浸润和皮肤硬化,与狼疮和炎性痣重叠。免疫组织化学显示表皮内和真皮表达CD3、CD8、TIA-1和CD45RA,可能与终末分化效应记忆细胞毒性T细胞(TEMRA)相对应。相比之下,与硬皮病发病有关的晚期记忆t细胞标志物CD57的表达在表皮中不存在,但在真皮中存在。本病例增加了FISARD的组织病理学发现谱,可能与多次透视检查的累积辐射损伤有关。鉴于越来越多的使用透视,识别这种组织病理学模式可以帮助及时和准确的诊断这种情况。讨论了记忆性CD8+ t细胞在疾病发病机制中的潜在作用。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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