Reference ranges of light-adapted full-field electroretinogram and associated factors in a large cohort of healthy school-aged children and adolescents.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2025-03-22 DOI:10.1007/s10633-025-10015-4

Sonia Seen-Hang Chan, Kai Yip Choi, Natalie Yu-Yan Chan, Vivian Wai Ying Lo, Angela Hing-Yiu Hung, Henry Ho-Lung Chan

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Abstract

Purpose: This study aimed to establish a reference data set of light-adapted full-field electroretinograms (ffERG) of healthy primary and secondary schoolchildren and investigate the relationship among refraction, ocular biometry, and ffERG.

Methods: Healthy children aged between 6 and 17 years were recruited. Cycloplegic spherical equivalent refraction (SER), axial length (AL) and keratometry (K) measurements were performed. Standardized ffERGs, including light-adapted flash and 30-Hz flicker, were measured using a portable device with skin electrodes. The percentiles of peak time and amplitude of a- and b-waves and 30-Hz flicker of ffERG waveform were reported, and their relationships with age, SER, AL, K were investigated.

Results: Among the 445 participants (45.4% female), the SER (mean ± standard deviation) was - 0.72 ± 2.06 D and AL was 23.56 ± 1.15 mm. The 90% confidence interval (CI) of 5th reference limit of amplitudes of a- and b-wave were 5.0-5.8 µV and 15.0-17.6 µV, while 95th reference limit of peak times were 13.2-13.4 ms and 29.8-30.0 ms, respectively. The amplitude and peak time of the 30-Hz flicker waveform were 21.5-23.9 µV and 26.0-26.2 ms, respectively. In general, more myopic SER, and longer AL were associated with delayed and reduced ffERG waveforms. Older age and male sex were weakly correlated with ffERGs with minimal clinical significance.

Conclusions: A reference data set of light-adapted ffERG in children and adolescents was established for clinical and research purposes.

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大队列健康学龄儿童和青少年光适应全视野视网膜电图参考范围及相关因素

目的：建立健康中小学生光适应全视野视网膜电图（ffERG）的参考数据集，探讨屈光、眼生物特征与ffERG之间的关系。方法：招募6 ~ 17岁的健康儿童。睫状体麻痹球等效折射（SER），轴长（AL）和角膜屈光度(K)测量。标准化ffERGs，包括光适应闪光和30赫兹闪烁，使用带有皮肤电极的便携式设备进行测量。报道了ffERG波形a波、b波峰值时间、振幅和30hz闪烁的百分位数，并探讨了它们与年龄、SER、AL、K的关系。结果：445名参与者（女性45.4%），SER（平均±标准差）为- 0.72±2.06 D， AL为23.56±1.15 mm。a波和b波振幅第5参考极限的90%置信区间（CI）分别为5.0 ~ 5.8µV和15.0 ~ 17.6µV，峰时间第95参考极限分别为13.2 ~ 13.4 ms和29.8 ~ 30.0 ms。30 hz闪烁波形的幅值为21.5 ~ 23.9µV，峰值时间为26.0 ~ 26.2 ms。一般来说，更多的近视SER和更长的AL与延迟和减少的ffERG波形有关。年龄和男性与ffERGs相关性较弱，临床意义不大。结论：为临床和研究目的建立了儿童和青少年适应光的ffERG参考数据集。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).