Innovative Fe(IV)-Triggered Chemiluminescence Assay for Rapid and Selective Detection of Total Phenolic Content

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2025-03-22 DOI:10.1021/acs.analchem.5c00552

Huixin Shao, Chengyu Gu, Huajie Li, Ling Chen, Xiaohong Guan

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引用次数: 0

Abstract

Total phenolic content reflecting the overall concentration of phenolics in water is a valuable indicator for evaluating water quality. However, current total phenolic content quantification technologies are unsatisfactory due to their complexity, time-consuming nature, limited reliability, and low selectivity. To overcome these problems, we utilized the high reactivity and selectivity of tetravalent iron (Fe(IV)) toward phenolics to develop a surrogate method for total phenolic content based on the quenching effect of phenolics on the chemiluminescence (CL) produced during the oxidation of naproxen (NAP) by Fe(IV) in the Fe(II)-activated periodate (Fe(II)/PI) process. Experimental results showed a strong linear relationship between the chemiluminescence quenching capacity (CLQC) values and total phenolic content in the Fe(II)/PI-NAP process. The high reactivity and superior selectivity of Fe(IV) toward phenolics enable rapid, highly sensitive, and robust anti-interference quantification of total phenolic content using the developed CL method. The limit of quantitation and limit of detection of the developed CL method for total phenolics determination were 1.34 and 0.40 μM, respectively, expressed as phenol equivalents. Finally, we validated the feasibility of using the CLQC value as a surrogate indicator for total phenolic content in various real water samples. This work introduces a novel method for quantifying total phenolic content by determining the CLQC value of water samples using the Fe(II)/PI-NAP process, offering a promising alternative for controlling the discharge of phenolics.

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用于快速、选择性检测总酚类物质含量的创新型铁（IV）触发化学发光测定法

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.