Lilia M. Beltrán-Barrientos*, José I. Méndez-Romero, María C. Estrada-Montoya, Adrián Hernández-Mendoza, Aarón F. González-Córdova, María de Jesús Torres-Llanez, Hugo S. García and Belinda Vallejo-Cordoba*,
{"title":"Gut Microbiota Modulation after the Administration of an Antihypertensive Milk Fermented with Lactococcus lactis NRRL B-50571","authors":"Lilia M. Beltrán-Barrientos*, José I. Méndez-Romero, María C. Estrada-Montoya, Adrián Hernández-Mendoza, Aarón F. González-Córdova, María de Jesús Torres-Llanez, Hugo S. García and Belinda Vallejo-Cordoba*, ","doi":"10.1021/acsfoodscitech.4c0062010.1021/acsfoodscitech.4c00620","DOIUrl":null,"url":null,"abstract":"<p >The aim of this study was to determine the effect of milk fermented with <i>Lactococcus lactis</i> NRRL B-50571 (FM-571) on gut microbiota (GM) of spontaneously hypertensive rats (SHRs), and its correlation with blood pressure (BP) short-chain-fatty acids (SCFAs) in feces, and antioxidant status in the plasma. Results showed that FM-571 increased (<i>p</i> < 0.05) diversity and reduced Firmicutes/Bacteroidetes ratio in GM. Moreover, FM-571 increased abundance (<i>p</i> < 0.05) of SCFA-producing bacteria <i>Prevotellaceae</i> (6.66 ± 3.29% and 7.29 ± 3.67%), <i>Lachnospiraceae</i> (21.38 ± 2.81% and 24.01 ± 12.32%), and <i>Ruminococcaceae</i> (21.82 ± 1.35 and 5.85 ± 0.3%) in feces and gut microbiota, respectively. Also, SCFAs in feces were higher (<i>p</i> < 0.05) in SHR treated with FM-571 and were negatively correlated to BP (<i>p</i> < 0.05). Additionally, <i>Verrucomicrobiota</i>, <i>Acidoaminococcaceae,</i> and <i>Akkermansiaceae</i> showed negative correlations with BP and oxidative stress index (<i>p</i> < 0.05) and positive correlations with the activity of antioxidant enzymes (<i>p</i> < 0.05). Overall, these results may suggest that the antihypertensive effect of FM-571 was linked to an improvement in the antioxidant status and SCFA production related to GM modulation.</p>","PeriodicalId":72048,"journal":{"name":"ACS food science & technology","volume":"5 3","pages":"953–963 953–963"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS food science & technology","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsfoodscitech.4c00620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of this study was to determine the effect of milk fermented with Lactococcus lactis NRRL B-50571 (FM-571) on gut microbiota (GM) of spontaneously hypertensive rats (SHRs), and its correlation with blood pressure (BP) short-chain-fatty acids (SCFAs) in feces, and antioxidant status in the plasma. Results showed that FM-571 increased (p < 0.05) diversity and reduced Firmicutes/Bacteroidetes ratio in GM. Moreover, FM-571 increased abundance (p < 0.05) of SCFA-producing bacteria Prevotellaceae (6.66 ± 3.29% and 7.29 ± 3.67%), Lachnospiraceae (21.38 ± 2.81% and 24.01 ± 12.32%), and Ruminococcaceae (21.82 ± 1.35 and 5.85 ± 0.3%) in feces and gut microbiota, respectively. Also, SCFAs in feces were higher (p < 0.05) in SHR treated with FM-571 and were negatively correlated to BP (p < 0.05). Additionally, Verrucomicrobiota, Acidoaminococcaceae, and Akkermansiaceae showed negative correlations with BP and oxidative stress index (p < 0.05) and positive correlations with the activity of antioxidant enzymes (p < 0.05). Overall, these results may suggest that the antihypertensive effect of FM-571 was linked to an improvement in the antioxidant status and SCFA production related to GM modulation.