Gut Microbiota Modulation after the Administration of an Antihypertensive Milk Fermented with Lactococcus lactis NRRL B-50571

IF 2.6 Q2 FOOD SCIENCE & TECHNOLOGY

ACS food science & technology Pub Date : 2025-02-24 DOI:10.1021/acsfoodscitech.4c0062010.1021/acsfoodscitech.4c00620

Lilia M. Beltrán-Barrientos*, José I. Méndez-Romero, María C. Estrada-Montoya, Adrián Hernández-Mendoza, Aarón F. González-Córdova, María de Jesús Torres-Llanez, Hugo S. García and Belinda Vallejo-Cordoba*,

{"title":"Gut Microbiota Modulation after the Administration of an Antihypertensive Milk Fermented with Lactococcus lactis NRRL B-50571","authors":"Lilia M. Beltrán-Barrientos*, José I. Méndez-Romero, María C. Estrada-Montoya, Adrián Hernández-Mendoza, Aarón F. González-Córdova, María de Jesús Torres-Llanez, Hugo S. García and Belinda Vallejo-Cordoba*, ","doi":"10.1021/acsfoodscitech.4c0062010.1021/acsfoodscitech.4c00620","DOIUrl":null,"url":null,"abstract":"The aim of this study was to determine the effect of milk fermented with Lactococcus lactis NRRL B-50571 (FM-571) on gut microbiota (GM) of spontaneously hypertensive rats (SHRs), and its correlation with blood pressure (BP) short-chain-fatty acids (SCFAs) in feces, and antioxidant status in the plasma. Results showed that FM-571 increased (p < 0.05) diversity and reduced Firmicutes/Bacteroidetes ratio in GM. Moreover, FM-571 increased abundance (p < 0.05) of SCFA-producing bacteria Prevotellaceae (6.66 ± 3.29% and 7.29 ± 3.67%), Lachnospiraceae (21.38 ± 2.81% and 24.01 ± 12.32%), and Ruminococcaceae (21.82 ± 1.35 and 5.85 ± 0.3%) in feces and gut microbiota, respectively. Also, SCFAs in feces were higher (p < 0.05) in SHR treated with FM-571 and were negatively correlated to BP (p < 0.05). Additionally, Verrucomicrobiota, Acidoaminococcaceae, and Akkermansiaceae showed negative correlations with BP and oxidative stress index (p < 0.05) and positive correlations with the activity of antioxidant enzymes (p < 0.05). Overall, these results may suggest that the antihypertensive effect of FM-571 was linked to an improvement in the antioxidant status and SCFA production related to GM modulation.","PeriodicalId":72048,"journal":{"name":"ACS food science & technology","volume":"5 3","pages":"953–963 953–963"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS food science & technology","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsfoodscitech.4c00620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The aim of this study was to determine the effect of milk fermented with Lactococcus lactis NRRL B-50571 (FM-571) on gut microbiota (GM) of spontaneously hypertensive rats (SHRs), and its correlation with blood pressure (BP) short-chain-fatty acids (SCFAs) in feces, and antioxidant status in the plasma. Results showed that FM-571 increased (p < 0.05) diversity and reduced Firmicutes/Bacteroidetes ratio in GM. Moreover, FM-571 increased abundance (p < 0.05) of SCFA-producing bacteria Prevotellaceae (6.66 ± 3.29% and 7.29 ± 3.67%), Lachnospiraceae (21.38 ± 2.81% and 24.01 ± 12.32%), and Ruminococcaceae (21.82 ± 1.35 and 5.85 ± 0.3%) in feces and gut microbiota, respectively. Also, SCFAs in feces were higher (p < 0.05) in SHR treated with FM-571 and were negatively correlated to BP (p < 0.05). Additionally, Verrucomicrobiota, Acidoaminococcaceae, and Akkermansiaceae showed negative correlations with BP and oxidative stress index (p < 0.05) and positive correlations with the activity of antioxidant enzymes (p < 0.05). Overall, these results may suggest that the antihypertensive effect of FM-571 was linked to an improvement in the antioxidant status and SCFA production related to GM modulation.

Abstract Image

查看原文本刊更多论文

服用乳酸乳球菌 NRRL B-50571 发酵的降压牛奶后的肠道微生物区系调节

本研究旨在探讨乳酸乳球菌NRRL B-50571 （mf -571）发酵乳对自发性高血压大鼠（SHRs）肠道菌群（GM）的影响及其与血压（BP）、粪便短链脂肪酸（SCFAs）和血浆抗氧化水平的相关性。结果显示FM-571升高(p <；0.05)，降低了GM中厚壁菌门/拟杆菌门的比例。此外，FM-571增加了丰度(p <；产生scfa的细菌Prevotellaceae（6.66±3.29%和7.29±3.67%）、Lachnospiraceae（21.38±2.81%和24.01±12.32%）和Ruminococcaceae（21.82±1.35和5.85±0.3%）在粪便和肠道微生物群中的含量分别为0.05)。粪便中SCFAs含量较高(p <；0.05)，与BP呈负相关(p <；0.05)。Verrucomicrobiota、Acidoaminococcaceae和Akkermansiaceae与BP和氧化应激指数呈负相关(p <；0.05)，且与抗氧化酶活性呈正相关(p <；0.05)。总的来说，这些结果可能表明FM-571的降压作用与GM调节相关的抗氧化状态和SCFA生成的改善有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS food science & technology

CiteScore

3.30

自引率

0.00%

发文量