{"title":"The emergent property of inhibitory control: implications of intermittent network-based fNIRS neurofeedback training.","authors":"Lingwei Zeng, Lidong Gai, Kewei Sun, Yimeng Yuan, Yuntao Gao, Hui Wang, Xiucao Wang, Zhihong Wen","doi":"10.3389/fnhum.2025.1513304","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that inhibitory control is supported by frontal cortex and small-world brain networks. However, it remains unclear how regulating the topology changes the inhibitory control. We investigated the effects of small-worldness upregulation training on resting-state networks via fNIRS neurofeedback training, which will contribute to a deeper insight of inhibitory control.</p><p><strong>Methods: </strong>A five-day training session was used to regulate the small-worldness of the frontal cortex, and the color-word Stroop task was tested before and after training. Fifty healthy adults were recruited and randomly assigned to the sham feedback group (sham group), or intermittent fNIRS-based brain network feedback group (fNIRS-NF group). On the basis of the exclusion of incomplete data, 45 valid data sets were retained and analyzed (sham: 21, fNIRS-NF: 24).</p><p><strong>Results: </strong>Training increased resting-state small-worldness and improved Stroop task performance, with a significant correlation between these changes (<i>r</i> = -0.32, <i>p</i> = 0.032). The fNIRS-NF group exhibited reduced hemodynamic activation (βvalue decreased, indicating lower cognitive load) during posttest and follow-up. Notably, the right dorsolateral prefrontal cortex (dlPFC) showed greater intra-regional connectivity increases than the left dlPFC, suggesting asymmetric plasticity.</p><p><strong>Conclusion: </strong>Intermittent fNIRS neurofeedback effectively modulates resting-state small-world networks and enhances inhibitory control, with effects sustained for at least one week. These findings highlight small-worldness as a novel target for cognitive interventions.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1513304"},"PeriodicalIF":2.4000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913857/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Human Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnhum.2025.1513304","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Studies have shown that inhibitory control is supported by frontal cortex and small-world brain networks. However, it remains unclear how regulating the topology changes the inhibitory control. We investigated the effects of small-worldness upregulation training on resting-state networks via fNIRS neurofeedback training, which will contribute to a deeper insight of inhibitory control.
Methods: A five-day training session was used to regulate the small-worldness of the frontal cortex, and the color-word Stroop task was tested before and after training. Fifty healthy adults were recruited and randomly assigned to the sham feedback group (sham group), or intermittent fNIRS-based brain network feedback group (fNIRS-NF group). On the basis of the exclusion of incomplete data, 45 valid data sets were retained and analyzed (sham: 21, fNIRS-NF: 24).
Results: Training increased resting-state small-worldness and improved Stroop task performance, with a significant correlation between these changes (r = -0.32, p = 0.032). The fNIRS-NF group exhibited reduced hemodynamic activation (βvalue decreased, indicating lower cognitive load) during posttest and follow-up. Notably, the right dorsolateral prefrontal cortex (dlPFC) showed greater intra-regional connectivity increases than the left dlPFC, suggesting asymmetric plasticity.
Conclusion: Intermittent fNIRS neurofeedback effectively modulates resting-state small-world networks and enhances inhibitory control, with effects sustained for at least one week. These findings highlight small-worldness as a novel target for cognitive interventions.
期刊介绍：
Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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