Gender difference in the association between composite dietary antioxidant index and all-cause mortality.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1523171

Lanzhi Duan, Rui Zeng, Jiang Wang, Sisi Hu, Weiye Wang

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引用次数: 0

Abstract

Background: Existing studies on the association between the composite dietary antioxidant index (CDAI) and all-cause mortality are controversial. We aimed to analyze the association of CDAI with all-cause mortality, and determine the influence of gender on this association.

Methods: The data of adult participants (age ≥ 18) from the National Health and Nutrition Examination Survey (NHANES) cycles spanning 2001 to 2018 were analyzed. The NHANES-issued identifiers for participants enabled the linkage of data from the NHANES Public Use Linked Mortality File.

Results: The study encompassed a sample of 15,651 individuals. The mean CDAI was 0.52 ± 6.06. The restricted cubic spline revealed that the hazard ratio (HR) of all-cause mortality decreased significantly with increasing CDAI. However, this negative association existed only when the CDAI was less than 5. Multivariate Cox regression analysis showed that compared to the first CDAI quartile, the HR of all-cause mortality was significantly decreased in the third and fourth quartiles (both p < 0.001), and the p-value of the trend test was <0.001. In the subgroup analysis, a notably strong negative association between CDAI and the risk of all-cause mortality was only observed in men (p for interaction <0.001).

Conclusion: Higher CDAI is associated with a reduced risk of all-cause mortality exclusively in adult males, underscoring the substantial influence of gender on this relationship.

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.