Wenxuan Wu, Fengge Chen, Hui Ma, Jiaxi Lu, Yanhong Zhang, Haisong Zhou, Yunqi Yang, Shuhui Nie, Rui Wang, Weixiao Yue, Min Li, Xiaoguang Yang
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引用次数: 0
Abstract
Background: Although protein supplementation may be desirable in the management of sarcopenia, the appropriate protein requirements for older adults with sarcopenia are presently unclear.
Objective: The aim of this study was to determine the protein requirements of older adults (65-81 year) with sarcopenia by using the indicator amino acid oxidation (IAAO) technology.
Methods: Nine older adults with sarcopenia (four male participants and five female participants) participated in the study, with protein intakes ranging from 0.1 to 1.8 g/(kg·d). Each participant consumed an adapted diet with a protein level of 1.0 g/(kg·d) and 1.7 resting energy expenditure (REE) for 2 day. Day 3 was the oxidation day of the study. Diets that delivered energy at a 1.5 × REE were isocaloric. The amounts of phenylalanine and tyrosine maintained at a constant across intakes. Therefore, phenylalanine and tyrosine were added to the protein doses of 0.1-1.5 g/kg, which was based on the highest dose of lactalbumin content [1.8 g/(kg·d)]. Applying a non-linear mixed-effects model analysis of F13CO2, the protein requirement was determined by identifying the breakpoint in the F13CO2 data with graded amounts of dietary protein.
Results: The mean estimated average requirement (EAR) and recommended nutrient intake (RNI) of protein for older adults with sarcopenia were 1.21 (95% CI: 0.95, 1.46) and 1.54 (95% CI: 1.13, 1.95) g/(kg·d), respectively.
Conclusions: To our knowledge, this is the first study of protein intake in older adults with sarcopenia and indicates that older adults with sarcopenia may require a higher intake of dietary protein.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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