Age-related variations in opening pressure in lumbar puncture: Implications for its interpretation in children

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2025-03-19 DOI:10.1016/j.braindev.2025.104347

Juan David Farfán-Albarracín , Cristina Lorena Ramírez-Sierra , Oscar Mauricio Espitia Segura , Ana Maritza Bedoya Morales , Sofy Helena Pérez Cárdenas , Jennifer Julieth Guzmán-Porras , Luisa Fernanda Lopéz Mora , Mateo Humberto Ramírez Salazar , Leydi Alexandra Ceballos Inga , María Camila Rueda-Rodríguez , Hugo Andrés Téllez Prada , Juan David Sanchez Rincón , Juan Camilo Castro Rubio , Ingrid Lemus Espitia , Juan David Guevara-Ramos

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引用次数: 0

Abstract

Introduction

Opening pressure in lumbar puncture (LP) is an important parameter in the diagnosis of various neurological diseases. In children pressures may vary according to age. This study aimed to analyze the variation of opening pressure in LP according to age in children.

Methods

All LPs performed between February 2017 and March 2023 were analyzed. Patients with modifying factors for opening pressure were excluded. Descriptive analysis was conducted, along with a comparison of means and medians, local regression, and quantile regression. To identify the most relevant cutoff points, graphical analyses were employed.

Results

The median opening pressure was 21.0 cm H₂O, with a 10th percentile (P10) of 10 and a 90th percentile (P90) of 32. An increase in opening pressure with age was found. Graphical analysis revealed a significant cutoff point at 96 months. The median opening pressure from 1 to 96 months of age was 19.2 cm H₂O, with a P10 of 8 and a P90 of 28.9. For children older than 96 months, the median was 22 cm H₂O, with a P10 of 11.8 and a P90 of 35.

Conclusion

Opening pressures in children vary with age, with no differences related to sex. Graphical analysis indicates that 96 months of age is an important cutoff point. Above this age, standard values could be used, up to 96 months of age, however, it is necessary to conduct studies for reference values. Opening pressure alone is not sufficient for the diagnosis of intracranial hypertension in children.

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.