Anticonstipation Activity of Garlic Fructans in Loperamide-Induced Constipated Mice: Impact of Polymerization Degree

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-03-18 DOI:10.1021/acs.jafc.4c12689

Yanna Hu, Xinyan Bai, Lingyu Li, Wenjing Yang, Laibing Sun, Jie Man, Xuguang Qiao, Xiaoming Lu

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Abstract

Constipation severely affects the quality of life, and current treatment strategies may cause adverse effects. Garlic fructans have shown great potential for improving gastrointestinal health. This study aimed to elucidate the protective effects and mechanisms of three garlic fructans with different degrees of polymerization (DPs) against loperamide (Lop)-induced constipated mice. The results showed that garlic fructans accelerated intestinal motility (0.57–1.05-fold) and alleviated colonic crypt shortening (1.42–1.97-fold). Furthermore, dysregulation of excitatory/inhibitory gastrointestinal hormones was significantly alleviated, accompanied by restored propionic and butyric acid production and ameliorated bile acid metabolism disorders. Garlic fructans also improved gut microbiota homeostasis in constipated mice by inhibiting harmful bacteria and promoting the growth of beneficial bacteria. Compared with high-DP garlic fructans, low-DP fructans exhibited stronger relieving effects on Lop-induced constipation symptoms in mice. In conclusion, this study demonstrated the anticonstipation activity of garlic fructans and revealed that low-DP garlic fructans were more effective in alleviating Lop-induced constipation.

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.