Therapeutic targeting of P2X receptors for orofacial pain

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-03-12 DOI:10.1016/j.brainresbull.2025.111301

Jing Zhang , Tianjuan Ju , Yaru Qin, Ming Hou, Lei Gao, Li-an Wu

引用次数: 0

Abstract

P2X receptors (P2XRs), membrane ion channels activated by extracellular adenosine 5’ -triphosphate (ATP), play a pivotal role in nociception by directly promoting pain signaling. Currently, antagonists targeting P2XRs have taken effect in alleviating various pain. The therapeutic potential of the P2X receptor family has become a central focus. Consequently, numerous research groups and pharmaceutical companies are actively engaged in developing novel P2XR antagonists. Furthermore, an increasing number of clinical trials on P2XR antagonists have obtained encouraging results. This review provides an overview of the structural characteristics and cellular localization of P2XRs, their molecular mechanisms and signaling pathways implicated in orofacial pain. Additionally, it explores the development of P2XR antagonists and their therapeutic application for managing orofacial pain. In conclusion, this review highlights the promising role of P2XRs as therapeutic targets for orofacial pain treatment.

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针对口面部疼痛的 P2X 受体治疗。

P2X 受体（P2XRs）是由细胞外 5' -三磷酸腺苷（ATP）激活的膜离子通道，通过直接促进疼痛信号传导，在痛觉中发挥着关键作用。目前，针对 P2XRs 的拮抗剂已在缓解各种疼痛方面取得成效。P2X 受体家族的治疗潜力已成为关注的焦点。因此，许多研究小组和制药公司都在积极开发新型 P2XR 拮抗剂。此外，越来越多的 P2XR 拮抗剂临床试验也取得了令人鼓舞的结果。本综述概述了 P2XR 的结构特征和细胞定位、其分子机制以及与口面部疼痛有关的信号通路。此外，它还探讨了 P2XR 拮抗剂的开发及其在治疗口面部疼痛方面的应用。总之，这篇综述强调了 P2XRs 作为口面部疼痛治疗靶点的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.