Antihyperalgesic effects of gabapentin and levetiracetam in a model of post-traumatic epilepsy.

IF 2.2 4区医学 Q3 PHYSIOLOGY

Physiology international Pub Date : 2025-03-13 Print Date: 2025-03-27 DOI:10.1556/2060.2025.00524

Recep Basaran, Mustafa Efendioglu, Metehan Akça, Duygu Ceman, Cumaali Demirtaş, Yunus Emre Sürmeneli, Mehmet Yildirim

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引用次数: 0

Abstract

Objective: This study aimed to investigate the role of levetiracetam (LEV) and gabapentin (GBP) on mechanical and thermal pain thresholds, as well as n-acetylcysteine (NAC) as an adjuvant, in the pentylenetetrazol (PTZ)-induced post-traumatic epilepsy (PTE) model after mild-traumatic brain injury (TBI) in male Sprague-Dawley rats.

Methods: Animals were randomly divided into 7 groups (Control, PTE, PTE+LEV, PTE+GBP, PTE+NAC, PTE+LEV+NAC and PTE+GBP+NAC). Rats received 50 mg kg-1 LEV, 100 mg kg-1 GBP, and combinations of these antiepileptics with 100 mg kg-1 NAC for 14 days after TBI.

Results: While the thermal pain threshold decreased significantly in the PTE group (P < 0.05), it increased in the PTE+LEV, PTE+GBP, and PTE+LEV+NAC groups (P < 0.05, P < 0.001 and P < 0.01, respectively). Interestingly, NAC alone did not affect the thermal pain threshold, but the combination of PTE+LEV+NAC increased the thermal pain threshold. Furthermore, PTE+GBP+NAC administration prevented the effect of GBP on the thermal pain threshold.

Conclusions: The presented study is the first to examine the effect of LEV and GBP in PTE. It was found that PTE decreased the thermal pain threshold, but LEV and GBP applied for 14 days prevented the decrease in PTE-related pain threshold and increased the thermal pain threshold. NAC, which was used as an adjuvant to support antiepileptic drugs, did not influence the thermal pain threshold alone; however, it increased the pain threshold more by potentiating the effect of LEV. Both LEV and GBP have an antihyperalgesic effect in the PTE model facilitated by PTZ, and NAC further reinforces the antihyperalgesic effect of LEV.

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加巴喷丁和左乙拉西坦在创伤后癫痫模型中的抗痛觉作用。

目的：研究左乙莱西坦（LEV）和加巴喷丁（GBP）对雄性Sprague-Dawley大鼠轻度颅脑损伤（TBI）后创伤后癫痫（PTE）模型机械痛阈和热痛阈的影响，以及n-乙酰半胱氨酸（NAC）作为辅助剂的作用。方法：将动物随机分为对照组、PTE组、PTE+LEV组、PTE+GBP组、PTE+NAC组、PTE+LEV+NAC组和PTE+GBP+NAC组。大鼠在TBI后接受50 mg kg-1 LEV、100 mg kg-1 GBP以及这些抗癫痫药物与100 mg kg-1 NAC联合用药14天。结果：PTE组热痛阈值明显降低（P < 0.05）， PTE+LEV、PTE+GBP、PTE+LEV+NAC组热痛阈值升高（P < 0.05、P < 0.001、P < 0.01）。有趣的是，NAC单独对热痛阈值没有影响，但PTE+LEV+NAC的组合增加了热痛阈值。此外，PTE+GBP+NAC可阻止GBP对热痛阈值的影响。结论：本研究首次研究了LEV和GBP对PTE的影响，发现PTE降低了热痛阈，但LEV和GBP应用14天阻止了PTE相关痛阈的降低，并增加了热痛阈。NAC作为辅助抗癫痫药物，单独对热痛阈值没有影响；然而，它通过增强LEV的作用，更多地增加了痛阈。在PTZ促进的PTE模型中，LEV和GBP均有抗痛觉作用，NAC进一步增强了LEV的抗痛觉作用。

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来源期刊

Physiology international Medicine-Physiology (medical)

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： The journal provides a forum for important new research papers written by eminent scientists on experimental medical sciences. Papers reporting on both original work and review articles in the fields of basic and clinical physiology, pathophysiology (from the subcellular organization level up to the oranizmic one), as well as related disciplines, including history of physiological sciences, are accepted.