The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial.
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Abstract
Background: Migraine, as a widespread neurological condition, substantially impacts quality of life, particularly among women. Therefore, this study aimed to explore the potential effects of alpha-linolenic acid (ALA) and L-carnitine co-supplementation on migraine symptoms, mental health, and life quality in women with migraine.
Methods: In this randomized, triple-blind, placebo-controlled trial, 80 women with migraine were randomly assigned to receive either ALA (1000 mg) plus L-carnitine (500 mg) or matching placebos daily for 12 weeks. Migraine characteristics, mental health parameters, and quality of life measures were assessed at baseline and study end.
Results: The intervention group demonstrated a significant reduction in migraine frequency (-2.96; 95% CI (-3.48, -2.45) vs -0.07; 95% CI (-0.68, 0.53), P < 0.001), severity (-1.6; 95% CI (-2.05, -1.15) vs - 0.44; 95% CI (-0.91, 0.02), P = 0.001), and duration (-4.9; 95% CI (-6.34, -3.45) vs -0.5; 95% CI (-1.06, 0.66) hours, P < 0.001) compared to the placebo group. Mental health improvements were observed in depression (-7.4; 95% CI (-9.24, -5.55) vs 0.05; 95% CI (-1.16, 1.26), P < 0.001), and anxiety scores (-5.7; 95% CI (-7.26, -4.14) vs - 0.65; 95% CI (-2.33, 1.03), P < 0.001). Quality of life measures showed significant enhancement, with increased migraine-specific quality of life (9.75; 95% CI (8.01, 11.49) vs 1.22; 95% CI (-0.66, 3.11), P < 0.001) and decreased headache impact test-6 scores (-8.57; 95% CI (-11.79, -5.36) vs -1.35; 95% CI (-3.41, 0.71), P = 0.005) in the intervention group compared to the controls.
Conclusion: Co-supplementation with ALA and L-carnitine may offer a promising adjuvant therapy for managing migraine in women, addressing both physical symptoms and psychological burdens.
背景：偏头痛作为一种广泛存在的神经系统疾病，严重影响生活质量，尤其是女性。因此，本研究旨在探讨α -亚麻酸（ALA）和左旋肉碱共同补充对偏头痛女性症状、心理健康和生活质量的潜在影响。方法：在这项随机、三盲、安慰剂对照试验中，80名偏头痛女性被随机分配接受ALA（1000毫克）加左旋肉碱（500毫克）或匹配的安慰剂，持续12周。在基线和研究结束时评估偏头痛特征、心理健康参数和生活质量指标。结果：干预组偏头痛发生率显著降低(-2.96；95% CI (-3.48, -2.45) vs -0.07；结论：联合补充ALA和左旋肉碱可能是治疗女性偏头痛的一种有希望的辅助治疗方法，可以解决身体症状和心理负担。试验注册：IRCT20121216011763N57。
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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