The prognostic value of adipokine receptors leptinR and adiponectinR1 in obesity-inducible solid tumours.

IF 2.5 4区生物学 Q3 CELL BIOLOGY

Histology and histopathology Pub Date : 2025-02-27 DOI:10.14670/HH-18-895

Isabella Bollen, Marit Bernhardt, Thore Thiesler, Franziska Isabelle Winterhagen, Andreas Türler, Manuel Ritter, Alexander Mustea, Glen Kristiansen

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引用次数: 0

Abstract

Background: With the rising incidence of life expectancy, obesity, and tumours, understanding the incretory influence of adipose tissue in tumorigenesis becomes increasingly important. As the adipokines leptin and adiponectin are released by fat tissue, we aimed to analyse the expression of their respective receptors in tumours for which an association with obesity is epidemiologically hypothesised.

Methods: The expression of leptinR and adipoR1 were analysed in cohorts of renal cell cancer (n=391), cervical cancer (n=155), vulvar cancer (n=107), and endometrial cancer (n=90) by immunohistochemistry and correlated with clinicopathological parameters including survival times.

Results: Expression of leptinR was high in renal cell cancer (62.2% of cases), vulvar carcinoma (50%), and endometrial cancer (80.5% of tissue-samples). High expression was associated with favourable clinicopathological markers and longer overall survival times in renal cell and vulvar cancer. AdipoR1 was only weakly expressed in all four tumour entities and did not show significant associations with clinicopathological parameters or prognosis.

Conclusion: High leptinR is a promising biomarker of favourable tumour outcomes in renal cell carcinoma and vulvar carcinoma.

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脂肪因子受体瘦素r和脂联素r1在肥胖诱导实体瘤中的预后价值。

背景：随着预期寿命、肥胖和肿瘤发病率的上升，了解脂肪组织在肿瘤发生中的增量影响变得越来越重要。由于脂肪因子瘦素和脂联素是由脂肪组织释放的，我们的目的是分析它们各自的受体在肿瘤中的表达，这些受体在流行病学上被假设与肥胖有关。方法：应用免疫组化方法分析肾细胞癌（391例）、宫颈癌（155例）、外阴癌（107例）和子宫内膜癌（90例）患者leptinR和adipoR1的表达情况，并与生存时间等临床病理参数进行相关性分析。结果：leptinR在肾细胞癌（62.2%）、外阴癌（50%）和子宫内膜癌（80.5%）组织中表达较高。在肾细胞癌和外阴癌中，高表达与有利的临床病理标志物和较长的总生存时间相关。AdipoR1仅在所有四种肿瘤实体中弱表达，与临床病理参数或预后没有显着关联。结论：高瘦素r是肾细胞癌和外阴癌预后良好的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histology and histopathology 生物-病理学

CiteScore

3.90

自引率

0.00%

发文量

232

审稿时长

2 months

期刊介绍： HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.