Reducing the Phytotoxicity of Tryptanthrin Derivatives for Controlling Plant Bacterial Canker and Wilt Diseases

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-03-11 DOI:10.1021/acs.jafc.4c12641

Mei Zhu, Guiping Ouyang

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引用次数: 0

Abstract

Herein, we synthesized 34 novel tryptanthrin derivatives, among which T7NHCO-series compounds showed great antibacterial activity againstXanthomonas axonopodis pv. citri,Pseudomonas syringae pv. actinidiae, andRalstonia solanacearum with EC₅₀ values ranging from 0.26 to 0.56 μg/mL. Meanwhile, these compounds exhibited low cytotoxicity against HEK-293. Additionally, compound T7NHCO can inhibit biofilm formation, damage bacterial morphology, downregulate the expression of bacterial chemotaxis-related proteins, cause bacterial necrosis, and effectively control citrus and kiwifruit canker (the curative and protective efficiency is 79.35 and 88.31%, respectively) diseases. However, compound T7NHCO exhibited a significant phytotoxicity to tobacco. Subsequently, based on the characteristic of tobacco wilt disease being prone to outbreak in weakly acidic soil conditions, we introduced the pH-responsive ZIF-8 drug delivery system. Fortunately, T7NHCO@ZIF-8 nanoparticles exhibited low phytotoxicity and noticeable activity against tobacco wilt disease. Above all, T7NHCO@ZIF-8 nanoparticles may be a promising green lead agent against plant bacterial diseases.

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降低色氨酸衍生物防治植物细菌性溃疡病和枯萎病的植物毒性

本文合成了34个新型的色氨酸衍生物，其中t7nhco系列化合物对轴索黄单胞菌具有较强的抗菌活性。柑橘，丁香假单胞菌pv。EC50值在0.26 ~ 0.56 μg/mL之间。同时，这些化合物对HEK-293具有较低的细胞毒性。化合物T7NHCO能抑制生物膜的形成，破坏细菌形态，下调细菌趋化相关蛋白的表达，引起细菌坏死，有效防治柑橘和猕猴桃溃疡病（治疗和保护效率分别为79.35%和88.31%）。化合物T7NHCO对烟草具有显著的植物毒性。随后，基于烟草萎蔫病在弱酸性土壤条件下容易爆发的特点，我们引入了ph响应型ZIF-8给药系统。幸运的是，T7NHCO@ZIF-8纳米颗粒表现出较低的植物毒性和显著的抗烟草枯萎病活性。最重要的是，T7NHCO@ZIF-8纳米颗粒可能是一种很有前途的绿色铅剂，可以预防植物细菌性疾病。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.