NTRK protein expression in NSCLC and its clinicopathological correlation.

IF 2.5 4区 生物学 Q3 CELL BIOLOGY
Jair Gutierrez-Herrera, M Angeles Montero-Fernandez, Luigi De Petris, Ricardo Guijarro, Simon Ekman, Cristian Ortiz-Villalón
{"title":"NTRK protein expression in NSCLC and its clinicopathological correlation.","authors":"Jair Gutierrez-Herrera, M Angeles Montero-Fernandez, Luigi De Petris, Ricardo Guijarro, Simon Ekman, Cristian Ortiz-Villalón","doi":"10.14670/HH-18-894","DOIUrl":null,"url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) is a complex disease with diverse clinical and molecular characteristics. Since the discovery of the oncogenic neurotrophic receptor tyrosine kinase (NTRK) gene fusion in colorectal cancer in 1986, its understanding has gradually progressed. NTRK's relevance is crucial to understanding some tumor development and how specific tyrosine receptor kinase inhibitors (TRKI) work. <i>NTRK1, NTRK2,</i> and <i>NTRK3</i> (encoding the neurotrophin receptors TRKA, TRKB, and TRKC, respectively) rearrangement induces high tumor transforming ability. This study investigates the clinical relevance of NTRK immunohistochemistry in NSCLC patients in a cohort of 482 patients from Karolinska University Hospital with detailed clinical and pathological studies. Immunohistochemical staining for NTRK expression was performed, and the results were correlated with patient demographics, histological subtypes, tumor extent, and staging. Our findings revealed that NTRK expression, predominantly membranous and cytoplasmic, was detected in 22 out of 482 cases (4.56%). Notably, NTRK expression was more frequently observed in squamous-cell carcinoma (SqCC) than in adenocarcinoma (AdCa). Clinical correlations indicated a significant association between NTRK expression and histologic subtypes (<i>p</i><0.001) and grade of differentiation (<i>p</i>=0.036). However, no significant correlations were observed with age, sex, tumor size, staging, or OS. NTRK immunohistochemistry represents a potential biomarker for a subset of NSCLC patients, particularly those with SqCC histology. Understanding the clinical implications of NTRK expression may contribute to personalized treatment strategies in NSCLC.</p>","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"18894"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histology and histopathology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.14670/HH-18-894","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Non-small cell lung cancer (NSCLC) is a complex disease with diverse clinical and molecular characteristics. Since the discovery of the oncogenic neurotrophic receptor tyrosine kinase (NTRK) gene fusion in colorectal cancer in 1986, its understanding has gradually progressed. NTRK's relevance is crucial to understanding some tumor development and how specific tyrosine receptor kinase inhibitors (TRKI) work. NTRK1, NTRK2, and NTRK3 (encoding the neurotrophin receptors TRKA, TRKB, and TRKC, respectively) rearrangement induces high tumor transforming ability. This study investigates the clinical relevance of NTRK immunohistochemistry in NSCLC patients in a cohort of 482 patients from Karolinska University Hospital with detailed clinical and pathological studies. Immunohistochemical staining for NTRK expression was performed, and the results were correlated with patient demographics, histological subtypes, tumor extent, and staging. Our findings revealed that NTRK expression, predominantly membranous and cytoplasmic, was detected in 22 out of 482 cases (4.56%). Notably, NTRK expression was more frequently observed in squamous-cell carcinoma (SqCC) than in adenocarcinoma (AdCa). Clinical correlations indicated a significant association between NTRK expression and histologic subtypes (p<0.001) and grade of differentiation (p=0.036). However, no significant correlations were observed with age, sex, tumor size, staging, or OS. NTRK immunohistochemistry represents a potential biomarker for a subset of NSCLC patients, particularly those with SqCC histology. Understanding the clinical implications of NTRK expression may contribute to personalized treatment strategies in NSCLC.

NTRK蛋白在非小细胞肺癌中的表达及其临床病理相关性
非小细胞肺癌(NSCLC)是一种复杂的疾病,具有多种临床和分子特征。自1986年在结直肠癌中发现致瘤性神经营养受体酪氨酸激酶(NTRK)基因融合以来,对其认识逐渐深入。NTRK的相关性对于理解某些肿瘤的发展和特异性酪氨酸受体激酶抑制剂(TRKI)的作用是至关重要的。NTRK1、NTRK2和NTRK3(分别编码神经营养因子受体TRKA、TRKB和TRKC)重排诱导高的肿瘤转化能力。本研究对来自卡罗林斯卡大学医院的482例非小细胞肺癌患者进行了详细的临床和病理研究,探讨了NTRK免疫组织化学在非小细胞肺癌患者中的临床意义。对NTRK表达进行免疫组化染色,结果与患者人口统计学、组织学亚型、肿瘤范围和分期相关。我们的研究结果显示,在482例病例中,有22例(4.56%)检测到NTRK表达,主要是膜和细胞质。值得注意的是,NTRK在鳞状细胞癌(SqCC)中的表达比在腺癌(AdCa)中更频繁。临床相关性显示NTRK表达与组织学亚型有显著相关性(pp=0.036)。然而,与年龄、性别、肿瘤大小、分期或OS没有显著相关性。NTRK免疫组织化学代表了一种潜在的非小细胞肺癌患者亚群的生物标志物,特别是那些具有SqCC组织学的患者。了解NTRK表达的临床意义可能有助于非小细胞肺癌的个性化治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Histology and histopathology
Histology and histopathology 生物-病理学
CiteScore
3.90
自引率
0.00%
发文量
232
审稿时长
2 months
期刊介绍: HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信