Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-03-07 DOI:10.1016/j.arr.2025.102728

Chao Song , Jiachen Yang , Zhongze Gu

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引用次数: 0

Abstract

Aging is a gradual and irreversible process accompanied by the decline in tissue function and a significantly increased risk of various aging-related and geriatric diseases. Especially in the paradoxical context of accelerated global aging and the widespread emergence of pandemics, aging-related and geriatric diseases have become leading causes of individual mortality and disability, drawing increasing attention from researchers and investors alike. Despite the utility of current in vitro systems and in vivo animal models for studying aging, these approaches are limited by insurmountable inherent constraints. In response, microphysiological systems (MPS), leveraging advances in tissue engineering and microfluidics, have emerged as highly promising platforms. MPS are capable of replicating key features of the tissue microenvironment within microfabricated devices, offering biomimetic tissue culture conditions that enhance the in vitro simulation of intact or precise human body structure and function. This capability improves the predictability of clinical trial outcomes while reducing time and cost. In this review, we focus on recent advancements in MPS used to study age-related and geriatric diseases, with particular emphasis on the application of organoids and organ-on-a-chip technologies in understanding cardiovascular diseases, cerebrovascular diseases, neurodegenerative diseases, fibrotic diseases, locomotor and sensory degenerative disorders, and rare diseases. And we aim to provide readers with critical guidelines and an overview of examples for modeling age-related and geriatric diseases using MPS, exploring mechanisms, treatments, drug screening, and other subsequent applications, from a physiopathological perspective, emphasizing the characteristic of age-related and geriatric diseases and their established correlations with the aging process. We also discuss the limitations of current models and propose future directions for MPS in aging research, highlighting the potential of interdisciplinary approaches to address unresolved challenges in the field.

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微生理系统（MPS）在衰老相关疾病和老年疾病研究中的最新进展

衰老是一个渐进的、不可逆的过程，伴随着组织功能的下降和各种衰老相关疾病和老年病的风险显著增加。特别是在全球加速老龄化和流行病广泛出现的矛盾背景下，与老龄化有关的疾病和老年疾病已成为个人死亡和残疾的主要原因，引起了研究人员和投资者越来越多的关注。尽管目前的体外系统和体内动物模型用于研究衰老，但这些方法受到不可克服的固有约束的限制。因此，利用组织工程和微流体技术的进步，微生理系统（MPS）已经成为非常有前途的平台。MPS能够在微制造设备中复制组织微环境的关键特征，提供仿生组织培养条件，增强完整或精确的人体结构和功能的体外模拟。这种能力提高了临床试验结果的可预测性，同时减少了时间和成本。在这篇综述中，我们将重点介绍MPS用于研究年龄相关疾病和老年疾病的最新进展，特别是类器官和器官芯片技术在心血管疾病、脑血管疾病、神经退行性疾病、纤维化疾病、运动和感觉退行性疾病以及罕见疾病方面的应用。我们的目标是从生理病理学的角度，为读者提供使用MPS建模年龄相关疾病和老年病的关键指南和示例概述，探索机制，治疗，药物筛选和其他后续应用，强调年龄相关疾病和老年病的特征及其与衰老过程的既定相关性。我们还讨论了当前模型的局限性，并提出了MPS在老龄化研究中的未来方向，强调了跨学科方法解决该领域未解决挑战的潜力。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.