Direction of TIS envelope electric field: Perpendicular to the longitudinal axis of the hippocampus

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-03-06 DOI:10.1016/j.jneumeth.2025.110416

Weiyu Meng , Cheng Zhang , Changzhe Wu , Xiaolin Huo , Guanghao Zhang

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引用次数: 0

Abstract

Background

Temporal Interference Stimulation (TIS) is a non-invasive approach to deep brain stimulation. However, most research has focused on the intensity of modulation, with limited attention given to the directional properties of the induced electric fields, despite their potential importance for precise stimulation.

New methods

A novel analytical framework was developed to analyze TIS-induced electric field directions using individual imaging data. For each voxel, the direction corresponding to the maximal modulation depth was calculated. The consistency of these directions within regions of interest (ROIs) and their alignment with the ROI principal axes, derived from principal component analysis (PCA), were assessed.

Results

Simulations revealed complex spatial and temporal trajectories of the electric field at the voxel level. In the left putamen, the maximal modulation depth reached 0.241 ± 0.041 V/m, whereas in the target region, the left hippocampus, it was lower (0.15 ± 0.032 V/m). Notably, in the left hippocampus, the directions of maximal modulation depth were predominantly perpendicular to its longitudinal axis (84.547 ± 8.776°), reflecting structural specificity across its anterior, middle, and posterior regions.

Comparison with existing methods

Unlike previous approaches, this study integrates directional analysis into TIS modeling, providing a foundation for precise stimulation by exploring structural alignment.

Conclusion

Our analysis revealed that the orientations of maximal modulation depth in the left hippocampus were perpendicular to its longitudinal axis under the current electrode configuration, but they shifted to parallel alignment when the electrode pairs were swapped. This directional specificity offers insights for optimizing TIS by aligning with structural features, presenting a potential strategy to enhance stimulation precision and broaden its clinical and research applications.

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TIS包络电场方向：与海马纵轴垂直。

背景：颞干扰刺激（TIS）是一种非侵入性的深部脑刺激方法。然而，大多数研究都集中在调制强度上，而对感应电场的定向特性的关注有限，尽管它们对精确刺激具有潜在的重要性。新方法：开发了一种新的分析框架，利用单个成像数据分析tis感应电场方向。对于每个体素，计算最大调制深度对应的方向。评估了这些方向在感兴趣区域（ROI）内的一致性以及它们与ROI主轴的对齐，这些方向来自主成分分析（PCA）。结果：模拟揭示了电场在体素水平上复杂的时空轨迹。左侧壳核最大调制深度为0.241±0.041V/m，左侧海马最大调制深度较低（0.15±0.032V/m）。值得注意的是，在左侧海马，最大调制深度的方向主要垂直于其纵轴（84.547±8.776°），反映了其前、中、后区域的结构特异性。与现有方法相比：与以往的方法不同，本研究将定向分析集成到TIS建模中，通过探索构造走向为精确增产奠定了基础。结论：我们的分析表明，在电流电极配置下，左侧海马最大调制深度的方向垂直于其纵轴，但当电极对交换时，它们转向平行排列。这种定向特异性为通过调整结构特征来优化TIS提供了见解，提出了提高刺激精度并扩大其临床和研究应用的潜在策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.