Laser driven 2D heterostructure nanocomposite membranes with bimodal photothermal and photodynamic functions

IF 8.4 1区 材料科学 Q1 CHEMISTRY, PHYSICAL
Congcong Wang , Yu Meng , Cuilu Xi , Yinyan Li , Jianbin Zhang , Junqiang Dong , Yanbang Lian , Shiqing Xu , Gongxun Bai , Xin Sun
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引用次数: 0

Abstract

To ablate tumor tissues safely and efficiently occupy a high priority in physical cancer therapy. However, it is still a challenge to realize high conversion efficiency of photothermal reagents and multi-functions with low health risks. Herein, nano-heterostructure membrane was synthesized by composting MoSe2:Nd nanosheets and graphene nanoflakes for improving the therapy efficiency and efficacy. It not only exerts fulfilling photothermal behaviors under 808 nm laser excitation, but also exhibits outstanding laser-induced photodynamic performance due to photogenerated carriers transfer from unique physical heterostructure. With bimodal photothermal/photodynamic therapy potential, the heterojunction structure is incorporated into the polydimethylsiloxane (PDMS) film and subcutaneously implanted into animate bodies, which further facilitate biomedical safety and experiment operability in tumor treatments, cutting off the possible risks arising from direct injection. In vitro photothermal properties and biomedical experiments strongly proof the composite film can exert intense photothermal response at laser excitation and possess considerably satisfactory biocompatibility, effectively eliminating tumor tissues without undesirable damage and pathological changes to normal organs.

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来源期刊
Journal of Materiomics
Journal of Materiomics Materials Science-Metals and Alloys
CiteScore
14.30
自引率
6.40%
发文量
331
审稿时长
37 days
期刊介绍: The Journal of Materiomics is a peer-reviewed open-access journal that aims to serve as a forum for the continuous dissemination of research within the field of materials science. It particularly emphasizes systematic studies on the relationships between composition, processing, structure, property, and performance of advanced materials. The journal is supported by the Chinese Ceramic Society and is indexed in SCIE and Scopus. It is commonly referred to as J Materiomics.
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