Laser driven 2D heterostructure nanocomposite membranes with bimodal photothermal and photodynamic functions

IF 8.4 1区 材料科学 Q1 CHEMISTRY, PHYSICAL
Congcong Wang , Yu Meng , Cuilu Xi , Yinyan Li , Jianbin Zhang , Junqiang Dong , Yanbang Lian , Shiqing Xu , Gongxun Bai , Xin Sun
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引用次数: 0

Abstract

To ablate tumor tissues safely and efficiently occupy a high priority in physical cancer therapy. However, it is still a challenge to realize high conversion efficiency of photothermal reagents and multi-functions with low health risks. Herein, nano-heterostructure membrane was synthesized by composting MoSe2:Nd nanosheets and graphene nanoflakes for improving the therapy efficiency and efficacy. It not only exerts fulfilling photothermal behaviors under 808 nm laser excitation, but also exhibits outstanding laser-induced photodynamic performance due to photogenerated carriers transfer from unique physical heterostructure. With bimodal photothermal/photodynamic therapy potential, the heterojunction structure is incorporated into the polydimethylsiloxane (PDMS) film and subcutaneously implanted into animate bodies, which further facilitate biomedical safety and experiment operability in tumor treatments, cutting off the possible risks arising from direct injection. In vitro photothermal properties and biomedical experiments strongly proof the composite film can exert intense photothermal response at laser excitation and possess considerably satisfactory biocompatibility, effectively eliminating tumor tissues without undesirable damage and pathological changes to normal organs.

Abstract Image

Abstract Image

具有双峰光热和光动力功能的激光驱动二维异质结构纳米复合膜
安全有效地消融肿瘤组织在肿瘤物理治疗中占有重要地位。然而,如何实现光热试剂的高转化效率和低健康风险的多功能,仍然是一个挑战。本文通过将MoSe2:Nd纳米片和石墨烯纳米片堆肥合成纳米异质结构膜,以提高治疗效率和疗效。它不仅在808 nm激光激发下表现出令人满意的光热行为,而且由于独特的物理异质结构产生的光致载流子转移,还表现出优异的激光诱导光动力学性能。具有双峰光热/光动力治疗潜力的异质结结构被纳入聚二甲基硅氧烷(PDMS)薄膜并皮下植入动物体内,进一步提高了肿瘤治疗的生物医学安全性和实验可操作性,消除了直接注射可能带来的风险。体外光热性能和生物医学实验有力地证明了复合膜在激光激发下能产生强烈的光热响应,具有相当满意的生物相容性,能有效地消除肿瘤组织,而不会对正常器官造成不良损伤和病理改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Materiomics
Journal of Materiomics Materials Science-Metals and Alloys
CiteScore
14.30
自引率
6.40%
发文量
331
审稿时长
37 days
期刊介绍: The Journal of Materiomics is a peer-reviewed open-access journal that aims to serve as a forum for the continuous dissemination of research within the field of materials science. It particularly emphasizes systematic studies on the relationships between composition, processing, structure, property, and performance of advanced materials. The journal is supported by the Chinese Ceramic Society and is indexed in SCIE and Scopus. It is commonly referred to as J Materiomics.
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