Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow.

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI:10.1038/s43587-025-00828-y

Haruhito Totani, Takayoshi Matsumura, Rui Yokomori, Terumasa Umemoto, Yuji Takihara, Chong Yang, Lee Hui Chua, Atsushi Watanabe, Takaomi Sanda, Toshio Suda

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Abstract

The aging of hematopoietic stem cells (HSCs) substantially alters their characteristics. Mitochondria, essential for cellular metabolism, play a crucial role, and their dysfunction is a hallmark of aging-induced changes. The impact of mitochondrial mass on aged HSCs remains incompletely understood. Here we demonstrate that HSCs with high mitochondrial mass during aging are not merely cells that have accumulated damaged mitochondria and become exhausted. In addition, these HSCs retain a high regenerative capacity and remain in the aging bone marrow. Furthermore, we identified GPR183 as a distinct marker characterizing aged HSCs through single-cell analysis. HSCs marked by GPR183 were also enriched in aged HSCs with high mitochondrial mass, possessing a high capacity of self-renewal. These insights deepen understanding of HSC aging and provide additional perspectives on the assessment of aged HSCs, underscoring the importance of mitochondrial dynamics in aging.

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富含线粒体的造血干细胞表现出更高的自我更新能力，在衰老的骨髓中茁壮成长。

造血干细胞（hsc）的老化大大改变了它们的特性。线粒体对细胞代谢至关重要，其功能障碍是衰老引起的变化的标志。线粒体质量对衰老造血干细胞的影响尚不完全清楚。在这里，我们证明了在衰老过程中具有高线粒体质量的造血干细胞不仅仅是积累了受损线粒体并变得精疲力竭的细胞。此外，这些造血干细胞在老化的骨髓中保留了很高的再生能力。此外，我们通过单细胞分析发现GPR183是表征衰老hsc的独特标记。GPR183标记的造血干细胞也在具有高线粒体质量、具有高自我更新能力的衰老造血干细胞中富集。这些见解加深了对HSC衰老的理解，并为衰老HSC的评估提供了额外的视角，强调了线粒体动力学在衰老中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

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