Minfang Luo, B. Dave Oomah, Winifred Akoetey, Yuqing Zhang, Hamed Daneshfozoun, Farah Hosseinian
{"title":"Liposomes as sustainable delivery systems in food, cosmetic, and pharmaceutical applications","authors":"Minfang Luo, B. Dave Oomah, Winifred Akoetey, Yuqing Zhang, Hamed Daneshfozoun, Farah Hosseinian","doi":"10.1002/aocs.12907","DOIUrl":null,"url":null,"abstract":"<p>Liposomes are artificial microscopic vesicles composed of phospholipid bilayers with the ability to encapsulate both hydrophobic and hydrophilic molecules, owing to the amphipathic nature of lipids. Hydrophobic molecules can be stored within the bilayer membrane, while hydrophilic molecules can be embedded in the inner core of liposomes. Encapsulated compounds within liposomes are protected from environmental and chemical alterations, such as enzymatic and chemical modifications, as well as changes against extreme pH, temperature, and ionic strength. Liposomes protective nature highlights their importance as nanocarriers for a wide spectrum of hydrophobic and hydrophilic molecules. This review offers a concise introduction to the fundamental physicochemical properties of liposomes and the various production methods including the role of cholesterol and potential alternatives such as phytosterols. It also provides an up-to-date overview of liposomes applications as delivery vehicles in food, cosmetics, and pharmaceuticals.</p>","PeriodicalId":17182,"journal":{"name":"Journal of the American Oil Chemists Society","volume":"102 3","pages":"547-568"},"PeriodicalIF":1.9000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aocs.12907","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Oil Chemists Society","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aocs.12907","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Liposomes are artificial microscopic vesicles composed of phospholipid bilayers with the ability to encapsulate both hydrophobic and hydrophilic molecules, owing to the amphipathic nature of lipids. Hydrophobic molecules can be stored within the bilayer membrane, while hydrophilic molecules can be embedded in the inner core of liposomes. Encapsulated compounds within liposomes are protected from environmental and chemical alterations, such as enzymatic and chemical modifications, as well as changes against extreme pH, temperature, and ionic strength. Liposomes protective nature highlights their importance as nanocarriers for a wide spectrum of hydrophobic and hydrophilic molecules. This review offers a concise introduction to the fundamental physicochemical properties of liposomes and the various production methods including the role of cholesterol and potential alternatives such as phytosterols. It also provides an up-to-date overview of liposomes applications as delivery vehicles in food, cosmetics, and pharmaceuticals.
期刊介绍:
The Journal of the American Oil Chemists’ Society (JAOCS) is an international peer-reviewed journal that publishes significant original scientific research and technological advances on fats, oils, oilseed proteins, and related materials through original research articles, invited reviews, short communications, and letters to the editor. We seek to publish reports that will significantly advance scientific understanding through hypothesis driven research, innovations, and important new information pertaining to analysis, properties, processing, products, and applications of these food and industrial resources. Breakthroughs in food science and technology, biotechnology (including genomics, biomechanisms, biocatalysis and bioprocessing), and industrial products and applications are particularly appropriate.
JAOCS also considers reports on the lipid composition of new, unique, and traditional sources of lipids that definitively address a research hypothesis and advances scientific understanding. However, the genus and species of the source must be verified by appropriate means of classification. In addition, the GPS location of the harvested materials and seed or vegetative samples should be deposited in an accredited germplasm repository. Compositional data suitable for Original Research Articles must embody replicated estimate of tissue constituents, such as oil, protein, carbohydrate, fatty acid, phospholipid, tocopherol, sterol, and carotenoid compositions. Other components unique to the specific plant or animal source may be reported. Furthermore, lipid composition papers should incorporate elements of yeartoyear, environmental, and/ or cultivar variations through use of appropriate statistical analyses.