The prevalence of Charles-Bonnet syndrome in ophthalmic patients: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-03-04 DOI:10.1016/j.brainresbull.2025.111282

Sophia E.G. Christoph , Karl T. Boden , Rudolf Siegel , Berthold Seitz , Peter Szurman , André Schulz

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引用次数: 0

Abstract

Objectives

Charles Bonnet Syndrome (CBS) involves visually impaired yet mentally healthy individuals experiencing visual hallucinations (VH) while being aware of the hallucinations’ unreality. Its prevalence varies across different conditions, with low vision, bilateral vision loss and advanced age being established as risk factors. This meta-analysis aims to comprehensively assess CBS literature with regard to CBS prevalence in ophthalmic patients.

Methods

A comprehensive literature search was conducted on June 11th and June 13th 2023, using the databases PubMed/MEDLINE and Web of Science. Data evaluation and extraction was accomplished by two separate authors. Study analysis was performed qualitatively, thereafter quantitatively by a subsequent meta-analysis, including subgroup assessments for variations among demographic and ophthalmic variables.

Results

49 eligible studies were identified, encompassing data from 20 303 patients. The collective prevalence of CBS in literature was determined to be 10.2 % (95 % confidence interval: 7.23 % – 14.1 %). Vision rehabilitation patients suffer most frequently from CBS (24.6 %). Patients with retinal diseases, low vision, and glaucoma suffer from CBS at similar rates. The prevalence of CBS among these cohorts spans from 11.8 % to 17.7 %. Age (p = 0.0013) and sex (p = 0.003) correlated statistically significantly with the prevalence of CBS.

Conclusions

CBS is prevalent among ophthalmic patients with various eye diseases, especially in the presence of low vision. Ophthalmologists should consider that about one in six patients with retinal diseases, glaucoma, or low vision they assessed might experience CBS. Awareness among medical professionals should be increased, as education provides patients with relief.

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目的查理斯-波奈综合症（CBS）是指视力受损但精神健康的人出现视觉幻觉（VH），同时意识到幻觉的不真实性。其发病率在不同情况下各不相同，低视力、双侧视力丧失和高龄已被确定为风险因素。本荟萃分析旨在全面评估有关眼科患者CBS患病率的CBS文献。方法于2023年6月11日和6月13日使用PubMed/MEDLINE和Web of Science数据库进行了全面的文献检索。数据评估和提取分别由两位作者完成。对研究进行了定性分析，随后进行了定量荟萃分析，包括对人口统计学和眼科变量之间的差异进行亚组评估。文献中 CBS 的总患病率为 10.2%（95% 置信区间：7.23% - 14.1%）。视力康复患者是 CBS 的高发人群（24.6%）。视网膜疾病、低视力和青光眼患者的 CBS 患病率相似。这些人群的 CBS 患病率从 11.8 % 到 17.7 % 不等。年龄（p = 0.0013）和性别（p = 0.003）与 CBS 的患病率有显著的统计学相关性。眼科医生应该考虑到，在他们评估过的视网膜疾病、青光眼或低视力患者中，每六名患者中就有一名可能患有 CBS。应提高医疗专业人员对这一问题的认识，因为教育可以减轻患者的痛苦。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.