{"title":"The role of neutrophils and their immunosuppressive effects on prostate cancer.","authors":"Yihaoyun Lou, Zhiguo Fan, Shancheng Ren","doi":"10.14670/HH-18-890","DOIUrl":null,"url":null,"abstract":"<p><p>Over the past decade, there has been a significant increase in the incidence of prostate cancer on a global scale, establishing it as the second most prevalent malignant tumor among European and American males. Neutrophils are myeloid immune cells that constitute a crucial proportion of inflammatory cells within the human circulatory system and actively contribute to the composition of the prostate tumor microenvironment (TME). Recent investigations have revealed that neutrophils are influenced by the surrounding tumor environment and possess a dual capacity to either promote or suppress cancer within the TME. Nevertheless, the precise mechanisms of neutrophils in prostate cancer remain inadequately elucidated. In this review, we aimed to comprehensively outline the character of neutrophils in the development and progression of prostate cancer while also exploring the clinical prognostic significance of the neutrophil-to-lymphocyte ratio (NLR).</p>","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"18890"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histology and histopathology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.14670/HH-18-890","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Over the past decade, there has been a significant increase in the incidence of prostate cancer on a global scale, establishing it as the second most prevalent malignant tumor among European and American males. Neutrophils are myeloid immune cells that constitute a crucial proportion of inflammatory cells within the human circulatory system and actively contribute to the composition of the prostate tumor microenvironment (TME). Recent investigations have revealed that neutrophils are influenced by the surrounding tumor environment and possess a dual capacity to either promote or suppress cancer within the TME. Nevertheless, the precise mechanisms of neutrophils in prostate cancer remain inadequately elucidated. In this review, we aimed to comprehensively outline the character of neutrophils in the development and progression of prostate cancer while also exploring the clinical prognostic significance of the neutrophil-to-lymphocyte ratio (NLR).
期刊介绍：
HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
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