Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study.
Daniel Fatori, Elizabeth Shephard, Danilo Benette, Nathalia Ferrazzo Naspolini, Grover Castro Guzman, Jaqueline Yu Ting Wang, Pedro Tótolo, Anthonieta Looman Mafra, Caio Isaias, Davi Pereira Dos Santos, Fabiele Baldino Russo, Gerson Kobayashi, Adriana Argeu, Monike Teixeira, Ana Claudia Mattiello-Sverzut, Maria Teresa Bechere Fernandes, Danila Cristina Petian-Alonso, Helena Brentani, Marilia Scliar, Paulo Alfonso Schüroff, Pedro Zuccolo, Rogério Lerner, Stephania Geraldini, Veronica Luiza Vale Euclydes, Alicia Matijasevich, Alline Cristina de Campos, André Carlos Ponce de Carvalho, André Fujita, Carla R Taddei, Maria Rita Passos-Bueno, Patricia Beltrão-Braga, Guilherme Vanoni Polanczyk
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Abstract
This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments.
期刊介绍：
This multidisciplinary journal is devoted to the publication of original, empirical, theoretical and review papers which address the interrelationship of normal and pathological development in adults and children. It is intended to serve and integrate the field of developmental psychopathology which strives to understand patterns of adaptation and maladaptation throughout the lifespan. This journal is of interest to psychologists, psychiatrists, social scientists, neuroscientists, paediatricians, and researchers.
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