Muhammad Imran, Xianyang Feng, Zhongke Sun, Hanan Al Omari, Gaoyang Zhang, Jiayu Zhu, Munirah F. Aldayel, Chengwei Li
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引用次数: 0
Abstract
Among the fungal diseases, Fusarium head blight (FHB), caused by Fusarium graminearum, is one of the most destructive disease affecting wheat. This pathogen poses significant threats to global wheat production, leading to substantial yield losses and contaminating grains with harmful mycotoxins. The chemical control of FHB has become increasingly challenging due to the rise of pathogen resistance, environmental concerns, and the effects of climate change. This review introduces a novel approach to disease management through spray-induced gene silencing (SIGS), a cutting-edge technology that uses double-stranded RNA (dsRNA) to silence critical genes in both the fungus and the host plant. This silencing reduces pathogen virulence and enhances plant resilience. A key innovation is the integration of nanotechnology to improve the delivery of dsRNA, addressing challenges related to stability, cellular uptake, and targeting efficiency in field conditions. Nanocarriers have revolutionized dsRNA delivery by improving its encapsulation efficiency, precision, and stability, compared to traditional methods. Advances in cost-effective dsRNA production, particularly through microbial expression systems, enable scalable and sustainable implementation of this technology. This review emphasizes the potential of nanocarrier systems in precision agriculture and highlights their role in replacing harmful chemical treatments with RNA interference (RNAi)-based solutions. RNAi-based approaches not only reduce reliance on synthetic chemicals, but also promote environmental sustainability by addressing fungicide resistance. However, challenges remain in large-scale field application, cost-effectiveness, and regulatory approval processes. Overcoming these hurdles will be crucial to unlocking the full potential of this technology. In conclusion, the combination of nanotechnology and SIGS-based dsRNA delivery offers a groundbreaking approach to managing Fusarium infections in wheat. This innovative strategy has the potential to minimize environmental impacts while enhancing global food security, paving the way for a more sustainable and resilient agricultural future.
在真菌病害中，小麦赤霉病（Fusarium head blight， FHB）是小麦最具破坏性的病害之一。这种病原体对全球小麦生产构成重大威胁，导致大量产量损失并使有害真菌毒素污染谷物。由于病原体耐药性的上升、环境问题和气候变化的影响，食品毒素的化学控制变得越来越具有挑战性。本文介绍了一种通过喷雾诱导基因沉默（SIGS）进行疾病管理的新方法，这是一种利用双链RNA （dsRNA）沉默真菌和寄主植物中的关键基因的尖端技术。这种沉默降低了病原体的毒力，增强了植物的恢复力。一个关键的创新是集成纳米技术来改善dsRNA的递送，解决与稳定性、细胞摄取和野外条件下靶向效率相关的挑战。与传统方法相比，纳米载体通过提高其封装效率、精度和稳定性，彻底改变了dsRNA的递送。成本效益的dsRNA生产的进步，特别是通过微生物表达系统，使这项技术的可扩展和可持续实施成为可能。这篇综述强调了纳米载体系统在精准农业中的潜力，并强调了它们在用基于RNA干扰（RNAi）的解决方案取代有害化学处理方面的作用。基于rnai的方法不仅减少了对合成化学品的依赖，而且通过解决杀菌剂耐药性问题促进了环境的可持续性。然而，在大规模的现场应用、成本效益和监管审批程序方面仍然存在挑战。克服这些障碍对于释放这项技术的全部潜力至关重要。总之，纳米技术和基于sigs的dsRNA传递的结合为管理小麦镰刀菌感染提供了一种突破性的方法。这一创新战略有可能最大限度地减少对环境的影响，同时加强全球粮食安全，为更可持续和更具抵御力的农业未来铺平道路。图形抽象
期刊介绍：
Chemical and Biological Technologies in Agriculture is an international, interdisciplinary, peer-reviewed forum for the advancement and application to all fields of agriculture of modern chemical, biochemical and molecular technologies. The scope of this journal includes chemical and biochemical processes aimed to increase sustainable agricultural and food production, the evaluation of quality and origin of raw primary products and their transformation into foods and chemicals, as well as environmental monitoring and remediation. Of special interest are the effects of chemical and biochemical technologies, also at the nano and supramolecular scale, on the relationships between soil, plants, microorganisms and their environment, with the help of modern bioinformatics. Another special focus is the use of modern bioorganic and biological chemistry to develop new technologies for plant nutrition and bio-stimulation, advancement of biorefineries from biomasses, safe and traceable food products, carbon storage in soil and plants and restoration of contaminated soils to agriculture.
This journal presents the first opportunity to bring together researchers from a wide number of disciplines within the agricultural chemical and biological sciences, from both industry and academia. The principle aim of Chemical and Biological Technologies in Agriculture is to allow the exchange of the most advanced chemical and biochemical knowledge to develop technologies which address one of the most pressing challenges of our times - sustaining a growing world population.
Chemical and Biological Technologies in Agriculture publishes original research articles, short letters and invited reviews. Articles from scientists in industry, academia as well as private research institutes, non-governmental and environmental organizations are encouraged.
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