Extracellular vesicles and bioactive peptides for regenerative medicine in cosmetology

IF 12.5 1区 医学 Q1 CELL BIOLOGY
Yize Yuan , Kailu Cao , Peifen Gao , Yinan Wang , Wenlin An , Yiyang Dong
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引用次数: 0

Abstract

As life quality improves and the life pressure increases, people’s awareness of maintaining healthy skin and hair grows. However, the use of bioactive peptides in regenerative medical aesthetics is often constrained by the high molecular weight, which impedes skin penetration. In contrast, extracellular vesicles not only possess regenerative properties but also serve as effective carriers for bioactive peptides. Given their anti-inflammatory and bactericidal properties, capacity to promote angiogenesis, optimize collagen alignment, facilitate re-epithelialization and stimulate hair growth, extracellular vesicles become an emerging and promising solution for skin regeneration treatments. The combination of peptides and extracellular vesicles enhances therapeutic efficacy and improves the bioavailability of bioactive peptides. In this review, we summarize the functions of bioactive peptides and plant- and animal-derived extracellular vesicles in regenerative medicine with cosmetology, along with examples of their combined applications. Additionally, we provide an overview of peptides and extracellular vesicles currently available on the market and in clinical practice, discussing the challenges and solutions associated with their use.
美容再生医学中的细胞外囊泡和生物活性肽。
随着生活质量的提高和生活压力的增大,人们对保持皮肤和头发健康的意识越来越强。然而,生物活性肽在再生医学美学中的应用往往受到高分子量的限制,这阻碍了皮肤渗透。相反,细胞外囊泡不仅具有再生特性,而且是生物活性肽的有效载体。由于细胞外囊泡具有抗炎和杀菌的特性,能够促进血管生成,优化胶原蛋白排列,促进上皮再生和刺激头发生长,因此成为皮肤再生治疗的新兴和有前途的解决方案。多肽与细胞外囊泡的结合提高了治疗效果,提高了生物活性多肽的生物利用度。本文综述了生物活性肽和动植物源性细胞外囊泡在再生医学和美容中的作用,并举例说明了它们的联合应用。此外,我们还概述了目前在市场上和临床实践中可用的肽和细胞外囊泡,讨论了与它们的使用相关的挑战和解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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