Seven New Guanidine Derivatives and One New Hypoxanthine Derivative Isolated from the Scorpion Buthus martensii and Potential Anti-Neuroinflammatory Activity.
IF 3.3
2区 生物学
Q2 CHEMISTRY, MEDICINAL
Journal of Natural Products
Pub Date : 2025-03-28
Epub Date: 2025-03-03
DOI:10.1021/acs.jnatprod.5c00040
引用次数: 0
Abstract
Twelve guanidine derivatives (1-12), including seven new compounds (martensiiagms A-G, 1-7), one new hypoxanthine derivative (martensiiagm H, 13), and 15 known compounds (14-28) were isolated from the whole body of Buthus martensii Karsch and identified by analysis of data. Subsequent biological evaluations revealed the anti-inflammatory activity of compound 1. It attenuates the neuroinflammation and oxidative stress levels prompted by lipopolysaccharide. This attenuation is accomplished by a specific action on mitochondria, which, in turn, caused a significant decrease in reactive oxygen species and pro-inflammatory cytokines.
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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