Chronic Candida albicans meningoencephalitis in a patient with mantle cell lymphoma: a diagnostic challenge.

Q2 Medicine
Johannes L Busch, Justus Schikora, Lisa-Marie Wackernagel, Jawed Nawabi, Matthias Endres, Klemens Ruprecht
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引用次数: 0

Abstract

Due to its unspecific clinical presentation and the multitude of possible etiologies, chronic meningoencephalitis in immunosuppressed patients often represents a diagnostic challenge. Here, we report the clinical, radiological, cerebrospinal fluid, and microbiological findings of a 54-year-old male immunocompromised patient with mantle cell lymphoma and a 2-month history of brainstem and spinal meningoencephalitis. After unsuccessful treatment trials with antibiotics, a Candida albicans infection was confirmed by biopsy of a spinal cord lesion and large-volume cerebrospinal fluid culture. Therapy with liposomal amphotericin B/flucytosine and subsequent fluconazole resulted in significant clinical improvement. This case illustrates the importance of identifying the underlying cause of chronic meningoencephalitides in immunocompromised patients.

慢性白色念珠菌脑膜脑炎伴套细胞淋巴瘤:一个诊断挑战。
由于其非特异性的临床表现和多种可能的病因,免疫抑制患者的慢性脑膜脑炎通常是一个诊断挑战。在此,我们报告一位54岁男性免疫功能低下患者的临床、影像学、脑脊液和微生物学检查结果,该患者患有套细胞淋巴瘤,并有2个月的脑干和脊膜脑炎病史。在抗生素治疗试验失败后,通过脊髓病变活检和大容量脑脊液培养证实了白色念珠菌感染。用两性霉素B/氟胞嘧啶脂质体和随后的氟康唑治疗可显著改善临床。本病例说明了确定免疫功能低下患者慢性脑膜脑碱潜在病因的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.40
自引率
0.00%
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0
审稿时长
14 weeks
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