Feasibility exploration of myocardial blood flow synthesis from a simulated static myocardial computed tomography perfusion via a deep neural network.

Abstract

Background:: Myocardial blood flow (MBF) provides important diagnostic information for myocardial ischemia. However, dynamic computed tomography perfusion (CTP) needed for MBF involves multiple exposures, leading to high radiation doses.

Objectives:: This study investigated synthesizing MBF from simulated static myocardial CTP to explore dose reduction potential, bypassing the traditional dynamic input function.

Methods:: The study included 253 subjects with intermediate-to-high pretest probabilities of obstructive coronary artery disease (CAD). MBF was reconstructed from dynamic myocardial CTP. A deep neural network (DNN) converted simulated static CTP into synthetic MBF. Beyond the usual image quality evaluation, the synthetic MBF was segmented and a clinical functional assessment was conducted, with quantitative analysis for consistency and correlation.

Results:: Synthetic MBF closely matched the referenced MBF, with an average structure similarity (SSIM) of 0.87. ROC analysis of ischemic segments showed an area under curve (AUC) of 0.915 for synthetic MBF. This method can theoretically reduce the radiation dose for MBF significantly, provided satisfactory static CTP is obtained, reducing reliance on high time resolution of dynamic CTP.

Conclusions:: The proposed method is feasible, with satisfactory clinical functionality of synthetic MBF. Further investigation and validation are needed to confirm actual dose reduction in clinical settings.