Effect of long-term moderate red wine consumption in CD1 female mice

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2025-02-19 DOI:10.1039/D5FO00435G
Emilia Garcia-Moruno, Ana-Belén Blázquez, Nereida Jiménez de Oya, Ana Esteban, Silvia Motta, Antonella Costantini, Pedro J. Sánchez-Cordón, Eva Pericuesta, Miguel A. Martín-Acebes, Alfonso Gutiérrez-Adán and Juan-Carlos Saiz
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Abstract

In the early 80s, the so-called “French paradox” was proposed, that is, a correlation between wine consumption, a diet rich in fats, and low mortality from coronary disease. Conversely, it is well established that excessive alcohol consumption increases the risk of cirrhosis and cancer, but few studies have investigated the effects of moderate alcohol consumption. However, all these conclusions were derived from epidemiological population studies that may be subject to distortions due to multiple factors. Here, the effect of moderate consumption of red wine on health throughout life was examined in a murine model. Different variables were evaluated in groups of female animals that were fed a standard or a fat diet throughout their adult life and given water, or wine or alcohol diluted in water in proportions similar to what is considered moderate consumption in humans. Our results showed few differences in most of the analyzed variables (body weight, liver profile and survival rate) between the different female mouse groups. The most remarkable findings were observed in the fat-diet groups that showed more frequent and severe liver lesions and a lower average ovarian weight. Moreover, moderate and prolonged ethanol consumption significantly affected telomere length only when the diet was high in fat, whereas wine consumption showed no difference compared to water, pointing to a possible predominant role of the compounds, particularly polyphenols present in wine. On the other hand, wine-drinking mice fed a fat diet had more oocytes than those in the ethanol-drinking group. Overall, our data suggest that long-term moderate red wine consumption does not substantially influence the health of female mice.

Abstract Image

长期适量饮用红葡萄酒对CD1雌性小鼠的影响。
80年代初,所谓的“法国悖论”被提出,即葡萄酒消费、富含脂肪的饮食和冠心病的低死亡率之间存在相关性。相反,过度饮酒会增加肝硬化和癌症的风险,这是众所周知的,但很少有研究调查适度饮酒的影响。然而,所有这些结论都来自流行病学人口研究,可能受到多种因素的扭曲。在这里,在小鼠模型中研究了适量饮用红酒对一生健康的影响。研究人员对一组雌性动物进行了不同的变量评估,这些雌性动物在成年后被喂食标准饮食或脂肪饮食,并被给予水、葡萄酒或稀释过的酒精,其比例与人类的适度摄入量相似。我们的结果显示,不同雌性小鼠组在大多数分析变量(体重、肝脏特征和存活率)上几乎没有差异。最显著的发现是在脂肪饮食组中观察到的,他们表现出更频繁和严重的肝脏病变,平均卵巢重量更低。此外,只有当饮食中脂肪含量高时,适度和长时间的乙醇摄入才会显著影响端粒长度,而与水相比,葡萄酒摄入没有表现出差异,这表明这些化合物,尤其是葡萄酒中存在的多酚可能起着主导作用。另一方面,喝葡萄酒的小鼠喂食脂肪饮食比那些喝酒精的小鼠有更多的卵母细胞。总的来说,我们的数据表明,长期适度饮用红酒不会对雌性小鼠的健康产生实质性影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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