Integration of focused ultrasound and dynamic imaging control system for targeted neuro-modulation

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-02-22 DOI:10.1016/j.jneumeth.2025.110391

K.M. Karthick Raghunath , Surbhi Bhatia Khan , T.R. Mahesh , Ahlam Almusharraf , Rubal Jeet , Mohammad Tabrez Quasim , Azeem Irshad , Fatima Asiri

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引用次数: 0

Abstract

Background

Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (tMS) have received widespread clinical use as techniques within a Non-Invasive Brain Stimulation (NIBS) domain, whose primary focus is modulation of neural activity to treat neurological and psychiatric disorders. Despite these advancements, precision targeting of deep brain structures remains a challenge faced with great need of another innovation that will improve precision and reduce the risks. A novel methodology integrating transcranial Focused Ultrasound (tFUS) with real-time functional imaging modalities, including functional Magnetic Resonance Imaging (fMRI) and Near-Infra-Red Spectroscopy (NIRS), is proposed in this study as the Integrated Focused Ultrasound and Real-Time Imaging Control System (IFURTICS).

Principle results

Closed loop algorithms employed by IFURTICS allow it to dynamically vary stimulation parameters in response to real-time feedback on neural activity, allowing for accurate targeting of sensitive networks while minimizing deleterious collateral effects.

Conclusions

Clinical trials using standard datasets of fMRI and NIRS have proved that the approach improved targeting accuracy by ∼18 %, reduced off-target effects by ∼55 % and enhanced therapeutic outcomes by 50 % over current methods, suggesting its potential as a transformative approach to precision neuro-modulation.

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聚焦超声与目标神经调节动态成像控制系统的集成

经颅直流电刺激（tDCS）和经颅磁刺激（tMS）作为非侵入性脑刺激（NIBS）领域的技术已经得到了广泛的临床应用，其主要重点是调节神经活动来治疗神经和精神疾病。尽管取得了这些进步，但对大脑深部结构的精确定位仍然是一个挑战，迫切需要另一项创新来提高精度和降低风险。本研究提出了一种将经颅聚焦超声（tFUS）与实时功能成像模式（包括功能磁共振成像（fMRI）和近红外光谱（NIRS））相结合的新方法，即集成聚焦超声和实时成像控制系统（IFURTICS）。IFURTICS采用的闭环算法允许它根据神经活动的实时反馈动态改变刺激参数，从而在最小化有害附带影响的同时精确瞄准敏感网络。使用fMRI和NIRS标准数据集的临床试验证明，与目前的方法相比，该方法将靶向准确性提高了~ 18 %，将脱靶效应降低了~ 55 %，并将治疗结果提高了50 %，这表明它有潜力成为一种精确神经调节的变革性方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.