{"title":"Pediatric Ewing's Sarcoma and Permanent Chemotherapy-Induced Alopecia: A Case-Control Study.","authors":"Madeline Lillich, Stuart Gold, Diana McShane","doi":"10.1111/pde.15907","DOIUrl":null,"url":null,"abstract":"<p><p>Permanent chemotherapy-induced alopecia (PCIA), defined as the persistence of hair loss for > 6 months following chemotherapy cessation, is a rare pediatric diagnosis. A retrospective chart review was conducted to characterize cases of PCIA not previously reported in pediatric Ewing's sarcoma (ES) patients after completion of therapeutic chemotherapy, comparing demographic factors, cumulative chemotherapy dosing, family history of hair loss, and treatment methodologies with a control group. Of 12 patients with an history of pediatric ES, three were diagnosed with PCIA. Our findings suggest that PCIA can occur after treatment for ES in the pediatric population and that treatments, including topical and oral minoxidil, can be beneficial but may not result in complete hair regrowth.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/pde.15907","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Permanent chemotherapy-induced alopecia (PCIA), defined as the persistence of hair loss for > 6 months following chemotherapy cessation, is a rare pediatric diagnosis. A retrospective chart review was conducted to characterize cases of PCIA not previously reported in pediatric Ewing's sarcoma (ES) patients after completion of therapeutic chemotherapy, comparing demographic factors, cumulative chemotherapy dosing, family history of hair loss, and treatment methodologies with a control group. Of 12 patients with an history of pediatric ES, three were diagnosed with PCIA. Our findings suggest that PCIA can occur after treatment for ES in the pediatric population and that treatments, including topical and oral minoxidil, can be beneficial but may not result in complete hair regrowth.
期刊介绍：
Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.
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