New insights into the antiadipogenic effect of dihydromyricetin by restoring lipid homeostasis between TG and PE in white adipose tissue

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-02-15 DOI:10.1016/j.fbio.2025.106151

Lu Liu , Nanxi Dong , Houxue Cui, Sihong Li, Xiang Ma, Dong Niu

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Abstract

Dihydromyricetin (DHM) is a natural flavonoid known for its anti-obesity properties. However, the mechanism by which DHM restores lipid homeostasis in white adipose tissue (WAT) affected by a high-fat diet (HFD) is not yet fully understood. In this study, lipidomics and transcriptomics were utilized to elucidate the role of DHM in the regulation of lipid remodeling and dysregulation. The in vivo results showed that DHM restored lipid homeostasis by balancing triglycerides (TG) and phosphatidylethanolamine in the epididymal WAT (eWAT) of obese mice on a high-fat diet (HFD). The in vitro results demonstrated that DHM-induced metabolic reprogramming inhibited adipogenesis. Furthermore, DHM reduced TG synthesis and lipid droplet formation in adipocytes by alleviating endoplasmic reticulum stress and disrupting mitochondrial homeostasis. This study elucidated the mechanism by which DHM alleviates lipid metabolism disorders, offering a theoretical foundation for its development as an anti-obesity drug.

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.