{"title":"Relationship between prognostic nutritional index and asthma: a cross-sectional analysis.","authors":"Zhimeng Jiang, Xingyu Zhu, Huixin Jiang, Donglin Zhao, Jianwei Tian","doi":"10.3389/fnut.2025.1467270","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Asthma is a chronic disease characterized by inflammation of the airways. The association between nutritional status, inflammation, and asthma has been well-documented, yet the relationship between the Prognostic Nutritional Index (PNI) and asthma remains unclear. This is a study to see whether there is a relationship between PNI and asthma prevalence.</p><p><strong>Methods: </strong>The present study employed data from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020, including a total of 7,869 adult participants were included in the analysis. Participants were categorized into four quartiles based on PNI levels. A multivariable regression model was employed for the purpose of evaluating the correlation between PNI and asthma. In order to ascertain the stability of the association across different populations, subgroup analyses were performed.</p><p><strong>Results: </strong>Higher PNI levels were significantly associated with lower asthma prevalence. In the complete adjusted model, each additional unit of PNI was associated with a 3% reduction in the prevalence of asthma [0.97 (0.95, 0.99)]. Trend analysis indicated a significant negative correlation between PNI and asthma (<i>p</i> for trend = 0.0041). Subgroup analyses showed a consistent negative association across different populations.</p><p><strong>Conclusion: </strong>The findings of our study indicated that lower PNI values were linked to an elevated odds prevalence of asthma. Early nutritional intervention and inflammation management in high-risk populations with low PNI may reduce the incidence and severity of asthma. Future prospective studies are needed to confirm this relationship.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1467270"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839445/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1467270","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
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Abstract
Background and objective: Asthma is a chronic disease characterized by inflammation of the airways. The association between nutritional status, inflammation, and asthma has been well-documented, yet the relationship between the Prognostic Nutritional Index (PNI) and asthma remains unclear. This is a study to see whether there is a relationship between PNI and asthma prevalence.
Methods: The present study employed data from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020, including a total of 7,869 adult participants were included in the analysis. Participants were categorized into four quartiles based on PNI levels. A multivariable regression model was employed for the purpose of evaluating the correlation between PNI and asthma. In order to ascertain the stability of the association across different populations, subgroup analyses were performed.
Results: Higher PNI levels were significantly associated with lower asthma prevalence. In the complete adjusted model, each additional unit of PNI was associated with a 3% reduction in the prevalence of asthma [0.97 (0.95, 0.99)]. Trend analysis indicated a significant negative correlation between PNI and asthma (p for trend = 0.0041). Subgroup analyses showed a consistent negative association across different populations.
Conclusion: The findings of our study indicated that lower PNI values were linked to an elevated odds prevalence of asthma. Early nutritional intervention and inflammation management in high-risk populations with low PNI may reduce the incidence and severity of asthma. Future prospective studies are needed to confirm this relationship.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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