Alleviation of hyperglycaemia and oxidative stress by fruit extracts of different cultivars of the cornelian cherry (Cornus mas L. and Cornus mas × Cornus officinalis) in rats with diabetes mellitus†

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2025-02-21 DOI:10.1039/D4FO05426A
Iryna Brodyak, Anna Moroz, Karolina Bernacka, Alicja Z. Kucharska and Nataliia Sybirna
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Abstract

The development of new cornelian cherry cultivars with stronger antidiabetic properties than those of previously studied Cornus mas L. extracts is essential. Accordingly, the aim of the present study was to assess the biological effects of fruit extracts derived from the ‘Uholok’ and ‘Koralovyi’ cultivars of C. mas and mix of two hybrids of C. mas × C. officinalis (‘Jerzy’ and ‘Tomasz’ cultivars) in rats with streptozotocin-induced diabetes mellitus. The quantitative and qualitative identification of bioactive substances in cornelian cherry fruits was conducted using HPLC-PDA. Fruit extracts from different cultivars were administered orally to rats with diabetes for 14 days at a dose of 20 mg per kg b.w. This resulted in a notable decrease in glucose-related parameters in the blood, proving the extracts’ effectiveness as inhibitors of α-glucosidase activity. The fruit extract from the hybrids showed the most pronounced effect among the studied extracts with regard to these indicators. In addition, the fruit extracts demonstrated a positive corrective impact on the metabolites of glycolysis (pyruvate and L-lactate) and lactate dehydrogenase activity. The extracts produced antioxidant effect in diabetic rats by reducing oxidative stress biomarkers in plasma. Extracts from fruits of the ‘Uholok’ and ‘Koralovyi’ cultivars exhibited a higher efficiency than the extracts from C. mas ‘Yantarnyi’ and ‘Flava’ cultivars. The biological effects of the fruit extract from the ‘Uholok’ cultivar are comparable to those of the ‘Podolski’ cultivar. These findings contribute to the understanding of the antidiabetic effect of the studied extracts and indicate their potential application as promising drugs.

Abstract Image

不同品种山茱萸果实提取物对糖尿病大鼠高血糖和氧化应激的缓解作用。
开发具有较强抗糖尿病特性的山茱萸新品种是十分必要的。因此,本研究的目的是评估“Uholok”和“Koralovyi”品种的果实提取物,以及“Jerzy”和“Tomasz”品种的两个杂交品种的果实提取物对链脲佐菌素诱导的糖尿病大鼠的生物学效应。采用高效液相色谱- pda对山茱萸果实中的生物活性物质进行了定性和定量鉴定。以20 mg / kg b.w的剂量给糖尿病大鼠口服不同品种的水果提取物14天,结果显示血液中葡萄糖相关参数显著降低,证明了提取物作为α-葡萄糖苷酶活性抑制剂的有效性。杂交种果实提取物对上述指标的影响最为显著。此外,果实提取物对糖酵解代谢产物(丙酮酸和l -乳酸)和乳酸脱氢酶活性有积极的纠正作用。该提取物通过降低血浆氧化应激生物标志物对糖尿病大鼠产生抗氧化作用。“Uholok”和“Koralovyi”品种的果实提取物比“Yantarnyi”和“Flava”品种的果实提取物效率更高。“Uholok”品种果实提取物的生物学效应与“Podolski”品种相当。这些发现有助于了解所研究的提取物的抗糖尿病作用,并表明其作为有前景的药物的潜在应用。
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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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