{"title":"Uncovering a gut microbiota-derived metabolite that triggers host cellular senescence","authors":"","doi":"10.1038/s43587-025-00831-3","DOIUrl":null,"url":null,"abstract":"During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"346-347"},"PeriodicalIF":17.0000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00831-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.
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