A halloysite nanotubes-based hybrid fluorous monolith as the mixed-mode sorbent for hydrophilic and hydrophobic interactions and its application for analysis of antibiotics from milk powder and milk samples

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-02-18 DOI:10.1016/j.foodchem.2025.143440

Cheng Lin , Jiarun Mao , Yihui Chen , Chunyan Hou , Xiaoqiang Qiao , Ningkun Wu , Tingting Wang

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引用次数: 0

Abstract

Determining the hydrophilic and hydrophobic antibiotics in milk and related products poses significant challenges due to their polarity differences and trace levels. Herein, we proposed a halloysite nanotubes-based hybrid fluorous monolith (HNTs-PFOTS monolith) as a sorbent for spin-tip solid-phase extraction (SPE). Leveraging the perfluorooctyl groups of the HNTs-PFOTS monolith, antibiotics can be adsorbed through hydrophilic and hydrophobic interactions. An analytical method was developed by combining the HNTs-PFOTS monolith-based spin-tip SPE method with liquid chromatography-tandem mass spectrometry. Under optimized conditions, the method exhibited excellent purification capabilities, low detection limits (0.01–0.03 μg/kg), high recoveries (80.0–112.3 %), and satisfactory reproducibility (intra-day RSDs of 0.4–8.8 % and inter-day RSDs of 1.0–10.9 %) for hydrophilic and hydrophobic antibiotics in milk and milk product samples. This study offers a novel approach for developing sorbents targeting antibiotics and provides a new analytical method for determining hydrophilic and hydrophobic antibiotics in food products.

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基于高岭土纳米管的杂化氟整体石作为亲疏水相互作用的混合模式吸附剂及其在奶粉和牛奶样品中抗生素分析中的应用

由于牛奶及相关产品中亲疏水抗生素的极性差异和痕量水平，对它们的测定提出了重大挑战。在此，我们提出了一种基于高岭土纳米管的杂化含氟单体（HNTs-PFOTS单体）作为自旋尖端固相萃取（SPE）的吸附剂。利用HNTs-PFOTS单体的全氟辛基基团，抗生素可以通过亲疏水相互作用被吸附。将HNTs-PFOTS单片自旋尖固相萃取法与液相色谱-串联质谱法相结合，建立了一种分析方法。在优化条件下，该方法对牛奶及乳制品中亲水性和疏水性抗生素具有良好的纯化能力，检出限低（0.01 ~ 0.03 μg/kg），回收率高（80.0 ~ 112.3 %），重现性好（日内rsd为0.4 ~ 8.8 %，日内rsd为1.0 ~ 10.9 %）。该研究为开发靶向抗生素的吸附剂提供了新的途径，并为食品中亲疏水抗生素的测定提供了新的分析方法。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.