Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency.

IF 5 2区 医学 Q1 OPHTHALMOLOGY
Ye He, Pearl Heumann, Melissa Weilin Song, Shin Kadomoto, Srinivas R Sadda, Ilina D Pluym, Irena Tsui
{"title":"Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency.","authors":"Ye He, Pearl Heumann, Melissa Weilin Song, Shin Kadomoto, Srinivas R Sadda, Ilina D Pluym, Irena Tsui","doi":"10.1167/iovs.66.2.36","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This prospective cohort study examined the use of optical coherence tomography angiography (OCTA) to detect in vivo retinal and choroidal variations associated with placental insufficiency, manifesting as fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP).</p><p><strong>Methods: </strong>Pregnant women were imaged with OCTA from gestational week 16 and every 4 weeks until week 36. Pregnancy outcomes were categorized into three groups: uncomplicated, complicated by late FGR, or complicated by HDP after 32 weeks. OCTA metrics, including retinal perfusion density (PD), vessel length density (VLD), and choriocapillaris flow deficits (CCFDs), were compared between groups.</p><p><strong>Results: </strong>In uncomplicated pregnancies, OCTA metrics remained stable throughout gestation. In contrast, the FGR group exhibited significant overall increases in superficial VLD (P = 0.016), decreases in deep VLD (P = 0.029), and increases in CCFDs (P = 0.002) throughout pregnancy when compared to the uncomplicated group. The HDP group showed significant overall decreases in both PD (P < 0.001) and VLD (P = 0.019) in the deep layer when compared to the uncomplicated group. Furthermore, CCFDs demonstrated strong potential for early prediction of FGR as early as week 16 (area under the curve = 0.73; P = 0.012).</p><p><strong>Conclusions: </strong>Our pilot study highlights the potential of OCTA to identify retinal and choroidal variations as biomarkers for pregnancy complications, particularly increased CCFDs in FGR.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 2","pages":"36"},"PeriodicalIF":5.0000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827859/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Investigative ophthalmology & visual science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/iovs.66.2.36","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: This prospective cohort study examined the use of optical coherence tomography angiography (OCTA) to detect in vivo retinal and choroidal variations associated with placental insufficiency, manifesting as fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP).

Methods: Pregnant women were imaged with OCTA from gestational week 16 and every 4 weeks until week 36. Pregnancy outcomes were categorized into three groups: uncomplicated, complicated by late FGR, or complicated by HDP after 32 weeks. OCTA metrics, including retinal perfusion density (PD), vessel length density (VLD), and choriocapillaris flow deficits (CCFDs), were compared between groups.

Results: In uncomplicated pregnancies, OCTA metrics remained stable throughout gestation. In contrast, the FGR group exhibited significant overall increases in superficial VLD (P = 0.016), decreases in deep VLD (P = 0.029), and increases in CCFDs (P = 0.002) throughout pregnancy when compared to the uncomplicated group. The HDP group showed significant overall decreases in both PD (P < 0.001) and VLD (P = 0.019) in the deep layer when compared to the uncomplicated group. Furthermore, CCFDs demonstrated strong potential for early prediction of FGR as early as week 16 (area under the curve = 0.73; P = 0.012).

Conclusions: Our pilot study highlights the potential of OCTA to identify retinal and choroidal variations as biomarkers for pregnancy complications, particularly increased CCFDs in FGR.

求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信