Joint effect of modifiable risk factors on Parkinson's disease: a large-scale longitudinal study.

IF 2.4 3区医学 Q3 NEUROSCIENCES

Frontiers in Human Neuroscience Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI:10.3389/fnhum.2025.1525248

Panlong Li, Xirui Zhu, Min Liu, Yanfeng Wang, Chun Huang, Junwei Sun, Shan Tian, Yuna Li, Yuan Qiao, Junting Yang, Shanshan Cao, Chaohua Cong, Lei Zhao, Jingjing Su, Dandan Tian

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引用次数: 0

Abstract

Introduction: Previous researches have often underestimated the diversity and combined effects of risk factors for Parkinson's disease (PD). This study aimed to identify how multiple modifiable risk factors collectively impact PD.

Methods: The study included 452,492 participants from the UK Biobank, utilizing genetic data and 255 phenotypic variables. A broad exposure association study was conducted across seven domains: socioeconomic status, medical history, psychosocial factors, physical measures, early life, local environment, and lifestyle. Risk scores of each domain for each participant were generated. The joint effects of modifiable and genetic risks assessed using Cox proportional hazards model. Population attributable fraction (PAF) was estimated to quantify contribution ratio of risk factors in different domains to the occurrence of PD.

Results: Multiple risk factors significantly (p < 1.96 × 10^-4) associated with PD was observed. The top 5 factors were hand grip strength (hazard ratio (HR) = 0.98, p = 1.59 × 10^-24), long-standing illness (HR = 1.38, p = 3.63 × 10^-20), self-reported nervousness (HR = 1.56, p = 5.9 × 10^-20), ever suffered from mental health concerns (HR = 1.42, p = 5.48 × 10^-18) and chest pain (HR = 1.42, p = 1.43 × 10^-18). Individuals with unfavorable medical history, psychosocial factors, physical measures, and lifestyle had an increased risk of PD by 33 to 51% compared to those with favorable factors (p < 0.001).

Discussion: Results indicated that addressing modifiable risk factors, especially in physical measures and psychological factors, could potentially prevent up to 33.87% of PD cases. In formulating prevention strategies, it is recommended to prioritize domains such as physical measures, psychosocial factors, lifestyle, and medical history.

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.