Ultrasound assisted deep eutectic solvent-based extraction of Montepulciano d’ Abruzzo grape seeds for the recovery of the grape seed oil and its biological evaluation

IF 6.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry: X Pub Date : 2025-02-01 DOI:10.1016/j.fochx.2025.102273

Lorenza Marinaccio , Giulia Gentile , Gokhan Zengin , Stefano Pieretti , Azzurra Stefanucci , Angelo Cichelli , Adriano Mollica

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引用次数: 0

Abstract

Grape seeds are by-products of vinification process. In this work, a green ultrasound-assisted extraction of grape seeds oil was performed by using the natural volatile deep eutectic solvent (NADES) menthol: thymol 1:1. The obtained oil was compared to that deriving from UAE with n-hexane in terms of fatty acids composition and biological activities. The content of linoleic acid was low for the DES extracted oil; the content of linolenic acid increased from 0.53 % to 5.18 %. The grape seeds oil extracted with DES showed the best total phenolic (18.65 mg GAE/g) and flavonoid (0.73 mg RE/g) contents and the highest results in FRAP, CUPRAC, MCA and Phosphomolybdenum assays. The oil extracted by DES also showed a higher amylase inhibition (0.57 mmol ACAE/g) than n-hexane extract (0.47 mmol ACAE/g). Finally, the anti-inflammatory activity was assessed in vivo through tree different assays, suggesting that their different fatty acids composition could be partially responsible for the significant anti-inflammatory effect of the grape seed oil extracted by NADES.

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来源期刊

Food Chemistry: X CHEMISTRY, APPLIED-

CiteScore

4.90

自引率

6.60%

发文量

315

审稿时长

55 days

期刊介绍： Food Chemistry: X, one of three Open Access companion journals to Food Chemistry, follows the same aims, scope, and peer-review process. It focuses on papers advancing food and biochemistry or analytical methods, prioritizing research novelty. Manuscript evaluation considers novelty, scientific rigor, field advancement, and reader interest. Excluded are studies on food molecular sciences or disease cure/prevention. Topics include food component chemistry, bioactives, processing effects, additives, contaminants, and analytical methods. The journal welcome Analytical Papers addressing food microbiology, sensory aspects, and more, emphasizing new methods with robust validation and applicability to diverse foods or regions.