The impact of a walnut-rich breakfast on cognitive performance and brain activity throughout the day in healthy young adults: a crossover intervention trial.

Abstract

A healthy diet is essential for optimal brain health and many bioactives from food are linked to cognitive benefits. To examine whether walnuts led to cognitive improvements throughout the day, 32 healthy young adults, aged 18-30, were tested in a double-blind, crossover pilot study, to compare the effects of a breakfast containing 50 g walnuts with a calorie-matched control containing no nuts. Cognition, mood, blood, and EEG measures were recorded at baseline and 2, 4, and 6 hours postprandially. Mood ratings for negative affect appeared worse following walnuts compared to control, possibly due to a general dislike of the intervention. However, walnuts elicited faster reaction times throughout the day on executive function tasks. Memory recall performance at 2 hours was worse for walnuts compared to control, but by 6 hours this finding was reversed with walnuts outperforming the control. EEG PSD analysis revealed differences in frontoparietal activity in the walnut condition compared to the control condition during memory recall and during executive function performance. These results may reflect between-treatment differences in cognitive effort or attentional processes while performing the tasks. Blood analysis revealed lower circulating non-esterified fatty acids and small increases in glucose availability following consumption of walnuts compared to control, suggesting enhanced glucose availability as one possible mechanism of action. Further investigations of other potential mechanisms are needed. Overall, these findings provide evidence for reaction time benefits throughout the day following a walnut-rich breakfast, while memory findings were mixed with benefits only observed later in the day. However, more research is needed into how diets containing walnuts might regulate cognitive improvements in humans postprandially and over the longer term.