Curcumin mitigates dichlorvos-initiated multi-organ dysfunction in rats by attenuating systemic oxidative stress and brain inflammatory mRNA transcripts

Adio Jamiu Akamo , Boluwatife Adenike Olagunju , Ofem Effiom Eteng , Iyabode Adekemi Kehinde , Adetutu Omolola Ojelabi , Mushafau Adewale Akinsanya , Adedayo Adebisi Adebisi , Tobi Stephen Adekunbi , Abiola Fatimoh Adenowo , Flourence Anifowose , Olufemi Mulkah Ajagun-Ogunleye , Jacob Kehinde Akintunde
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Abstract

Organophosphorus pesticides like dichlorvos (DDVP) are widely used for pest control, however their safety is a growing concern due to potential multi-factorial health risks. While curcumin (CUR) is known for its antioxidant capacity, its influence on DDVP-incited multi-organ dysfunction and brain inflammation remain under-researched. This work assessed the ameliorative competence of CUR in a DDVP-mediated systemic intoxication rat model. Rats (42) were randomly appropriated into seven groups (6 rats/group): Control, DDVP only (20 mg.kg⁻¹day⁻¹), DDVP subjected with either CUR (50 and 100 mg.kg⁻¹day⁻¹) or the reference drug atropine (0.2 mg.kg⁻¹day⁻¹), and CUR only (50 and 10 mg.kg⁻¹day⁻¹) were investigated. Rats were afflicted with DDVP orally for seven days, followed by fourteen days of CUR intervention. We humanely killed the rats and harvested their blood and viscera (liver, kidney, heart, lung, and brain) for bioassays twenty-four hours following the final treatment. CUR significantly (p < 0.05) abrogated DDVP-engendered elevations in H₂O₂, NO, and malondialdehyde contents, as well as GST activity; and reversed DDVP-elicited declines in GSH amounts, activities of SOD, catalase, and glutathione peroxidase in across all tissues. In the brain, CUR markedly (p < 0.05) rescinded DDVP-occasioned upregulation of gene expression biomarkers for fibrosis (TGF-β-1), apoptosis regulator (nuclear factor-kB-p65), and pro-apoptosis (p53 and Bax); and markedly abated DDVP-provoked repression of anti-inflammatory cytokine (interleukin-10)]. Wholly CUR therapy mitigated DDVP-engendered multi-organ impairments in rats via rescinding oxidative stress and brain inflammation.
姜黄素通过减轻全身氧化应激和脑炎症mRNA转录物,减轻敌敌畏引起的大鼠多器官功能障碍
敌敌畏(DDVP)等有机磷农药被广泛用于害虫防治,但由于其潜在的多因素健康风险,其安全性日益受到关注。虽然姜黄素(CUR)以其抗氧化能力而闻名,但其对ddvp引发的多器官功能障碍和脑部炎症的影响仍未得到充分研究。本研究在ddvp介导的全身中毒大鼠模型中评估了CUR的改善能力。大鼠(42只)被随机分为7组(每组6只):对照组,只使用DDVP(20 mg.kg⁻¹天),使用DDVP(50和100 mg.kg⁻¹天)或对照药物阿托品(0.2 mg.kg⁻¹天)和只使用CUR(50和10 mg.kg⁻¹天)。大鼠口服DDVP 7天,然后进行14天的CUR干预。我们人道地杀死老鼠,并在最后治疗后24小时采集它们的血液和内脏(肝、肾、心、肺和脑)进行生物测定。CUR显著(p <; 0.05)消除了ddvp引起的H₂O₂、NO和丙二醛含量升高以及GST活性;并逆转了ddvp引起的GSH量、SOD、过氧化氢酶和谷胱甘肽过氧化物酶活性在所有组织中的下降。在脑内,CUR显著(p <; 0.05)消除了ddvp引起的纤维化(TGF-β-1)、凋亡调节因子(核因子- kb -p65)和促凋亡(p53和Bax)基因表达上调;并明显减弱ddvp引起的抗炎细胞因子(白细胞介素-10)的抑制]。完全CUR治疗通过消除氧化应激和脑炎症减轻了ddvp引起的大鼠多器官损伤。
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