DNA aptamer-crosslinked hydrogel sensor: Design, mechanism and application for food safety analysis

IF 15.1 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology Pub Date : 2025-02-01 DOI:10.1016/j.tifs.2024.104846

Xinning Wang , Liuqin He , Xiaoxiao Rong , Ling Liu , Yulong Yin , Xiaoying Zhao , Yunxuan Weng

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引用次数: 0

Abstract

Development of efficient detection strategies for food contaminants is essential for ensuring food safety and preventing foodborne disease. Despite their effectiveness, prevailing approaches face limitations such as complex instrumentation, prolonged process, high cost, and low sensitivity. DNA aptamers are promising novel recognition elements for food contaminants due to their high affinity and specificity for target substance. They can crosslink DNA-modified polymers through complementary base pairing to develop hydrogel sensors. The specific aptamer-target binding competes with aptamer-polymer crosslinking. This competition leads to hydrogel breakdown and a gel-sol transition, generating physical, chemical, electrical or other signals for target analysis. DNA aptamer-crosslinked hydrogel sensors offer significant advantages over traditional sensing techniques, including high accuracy, sensitivity, selectivity, rapid response and low cost. These attributes make them increasingly valuable for food safety analysis, especially for on-site and real-time monitoring. This review provides an insightful overview of the most recent advancements in DNA aptamer-crosslinked hydrogel sensors, focusing on their design, mechanism, applications in food safety analysis, important challenges and future research directions.

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来源期刊

Trends in Food Science & Technology 工程技术-食品科技

CiteScore

32.50

自引率

2.60%

发文量

322

审稿时长

37 days

期刊介绍： Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry. Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.