First episode of catatonia followed by a psychotic episode related to chronic nitrous oxide use: A case report.

IF 3 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review Pub Date : 2025-02-03 DOI:10.1111/dar.14012

Tanguy Taillefer de Laportalière, Maximilien Redon, Anne Roussin, Estelle Willemet, Etienne Very, Jean Olivier, Maryse Lapeyre-Mestre

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引用次数: 0

Abstract

Introduction: Nitrous oxide is widely used for recreational purposes, leading to constantly increasing cases of severe use disorder. Although the scope of the deleterious consequences of nitrous oxide use is relatively well described for neurological and thromboembolic-related complications, this is not the case in the psychiatric field.

Case presentation: We report the case of a 20-year-old woman who developed nitrous oxide-induced peripheral neuropathy. The patient had a history of frequent nitrous oxide use. One year later, she presented with catatonia linked to nitrous oxide use, associated with vitamin B12 deficiency and hyperhomocysteinemia, with no apparent psychiatric causes. Nine months after the catatonic episode, she experienced a psychotic episode linked to long-term nitrous oxide use.

Discussion and conclusion: To the best of our knowledge, this is the first report describing a cascade of neurologic and psychiatric complications of chronic use of nitrous oxide. Hyperhomocysteinemia caused by nitrous oxide consumption could explain the occurrence of such events. Homocysteine, methylmalonic acid, and active vitamin B12 are key biomarkers to determine the involvement of nitrous oxide in psychiatric symptoms.

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来源期刊

Drug and alcohol review SUBSTANCE ABUSE-

CiteScore

4.80

自引率

10.50%

发文量

151

期刊介绍： Drug and Alcohol Review is an international meeting ground for the views, expertise and experience of all those involved in studying alcohol, tobacco and drug problems. Contributors to the Journal examine and report on alcohol and drug use from a wide range of clinical, biomedical, epidemiological, psychological and sociological perspectives. Drug and Alcohol Review particularly encourages the submission of papers which have a harm reduction perspective. However, all philosophies will find a place in the Journal: the principal criterion for publication of papers is their quality.