Guidelines for assessing the capacity of food-derived nutrients to alleviate intestinal inflammation

Jinfan Yang, Zhengqing Li, Ning Shang, Hui Zhou, Mingzhen Zhang, Guanying Li, Huafeng Kang, Xiaobin Ma, Hao Wu
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Abstract

​Nutrients derived from food sources, such as astaxanthin, polyphenols, dietary fiber, probiotics, and short-chain fatty acids, play a crucial role in alleviating intestinal inflammation caused by sub-health conditions.​ These sub-health states are closely associated with a range of diseases, including colitis, gastric ulcers, and colorectal cancer. Currently, there is a lack of comprehensive guidelines that summarize quantitative and dynamic analysis methods for assessing the impact of nutrients on gastrointestinal inflammation, which limits accurate comparison and analysis of their mechanisms of action. Therefore, we summarized guidelines for evaluating the in vivo anti-inflammatory properties of food-derived nutrients. These guidelines encompass the selection of experimental models, dynamic assessment tools, long-term evaluation parameters, and exploration of inflammation-related mechanisms by disease activity index, murine endoscopic index of colitis severity (MEICS), spleen index, changes in colon length, and histology index, assessing inflammatory progression and tissue repair capabilities. By integrating these methods, researchers can conduct in-depth studies and systematic comparative analyses of the mechanisms by which food-derived nutrients alleviate intestinal inflammation. This approach will enable a more comprehensive understanding of the role of nutrition in gastrointestinal health and disease prevention.

Abstract Image

评估食物来源营养素减轻肠道炎症能力的指南
来自食物来源的营养物质,如虾青素、多酚、膳食纤维、益生菌和短链脂肪酸,在减轻亚健康状况引起的肠道炎症方面发挥着至关重要的作用。这些亚健康状态与一系列疾病密切相关,包括结肠炎、胃溃疡和结直肠癌。目前,缺乏综合的指南来总结评估营养物质对胃肠道炎症影响的定量和动态分析方法,这限制了对其作用机制的准确比较和分析。因此,我们总结了评估食物来源营养素体内抗炎特性的准则。这些指南包括实验模型的选择、动态评估工具、长期评估参数,以及通过疾病活动性指数、小鼠内镜下结肠炎严重程度指数(MEICS)、脾脏指数、结肠长度变化和组织学指数来探索炎症相关机制,评估炎症进展和组织修复能力。通过这些方法的整合,研究人员可以对食源性营养素缓解肠道炎症的机制进行深入的研究和系统的比较分析。这种方法将使人们更全面地了解营养在胃肠道健康和疾病预防中的作用。
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